Preparing molecules with multiple 13C labels is difficult owing to the lack of available 13C-labelled reagents. Now, a hydroformylation approach to the synthesis of [13C3]propionaldehyde, using gas surrogates, provides a straightforward method to prepare bioactive molecules with three 13C labels.
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Doyle, M.G.J., Lundgren, R.J. Triple 13C-labelling via hydroformylation. Nat. Synth 2, 205–206 (2023). https://doi.org/10.1038/s44160-022-00229-8
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DOI: https://doi.org/10.1038/s44160-022-00229-8
