Catalytic intramolecular C–H amination via nitrene transfer typically yields N-heterocycles which can be unmasked to amino alcohols and diamines. Now, an enantioselective Co-catalysed 1,5-C–H amination to form cyclic sulfamidates from alcohols allows for ring opening to deliver diverse β-functionalized chiral amines.
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References
Reddy, R. P. & Davies, H. M. L. Org. Lett. 8, 5013–5016 (2006).
Zhou, Z. et al. Chem 6, 2024–2034 (2020).
Lang, K., Hu, Y., Lee, W.-C. C. & Zhang, X. P. Nat. Synth. https://doi.org/10.1038/s44160-022-00107-3 (2022).
Lang, K., Torker, S., Wojtas, L. & Zhang, X. P. J. Am. Chem. Soc. 141, 12388–12396 (2019).
Adams, C. S., Boralsky, L. A., Guzei, I. A. & Schomaker, J. M. J. Am. Chem. Soc. 134, 10807–10810 (2012).
Bower, J. F., Rujirawanich, J. & Gallagher, T. Org. Biomol. Chem. 8, 1505–1519 (2010).
Cardona, F. & Goti, A. Nat. Chem. 1, 269–275 (2009).
Pendem, N. et al. J. Am. Chem. Soc. 135, 4884–4892 (2013).
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Zerull, E.E., Schomaker, J.M. Chiral amine synthesis refashioned. Nat. Synth 1, 506–507 (2022). https://doi.org/10.1038/s44160-022-00110-8
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DOI: https://doi.org/10.1038/s44160-022-00110-8
