The Kolbe electrolysis is a transformation renowned for forging C(sp3)–C(sp3) bonds. However, it is challenging to selectively make cross-products — that is, form new bonds from different partners — using this reaction. Now, a nickel-catalysed ‘reductive Kolbe’ reaction enables a decarboxylative cross-coupling approach.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Zhang, B. et al. Nature https://doi.org/10.1038/s41586-022-04691-4 (2022).
Harenbrock, M., Matzeit, A. & Schäfer, H. J. Liebigs Ann. 55–62 (1996).
Twilton, J., Le, C., Zhang, P., Shaw, M. H., Evans, R. W. & MacMillan, D. W. C. Nat. Rev. Chem. 1, 0052 (2017).
Johnston, C. P., Smith, R. T., Allmendinger, S. & MacMillan, D. W. C. Nature 536, 322–325 (2016).
Gandeepan, P., Finger, L. H., Meyer, T. H. & Ackermann, L. Chem. Soc. Rev. 49, 4254–4272 (2020).
Mori, K., Masuda, S. & Suguro, T. Tetrahedron 37, 1329–1340 (1981).
Horn, E. J., Rosen, B. R. & Baran, P. S. ACS Cent. Sci. 2, 302–308 (2016).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Zhang, S., Findlater, M. Kolbe reaction goes reductive. Nat. Synth 1, 417–419 (2022). https://doi.org/10.1038/s44160-022-00088-3
Published:
Issue Date:
DOI: https://doi.org/10.1038/s44160-022-00088-3