CD8+ T cells recognize tumor-associated antigens presented by major histocompatibility complex (MHC) class I molecules. How CD8+ T cells eliminate cancer cells deficient in MHC class I has been unclear. A study now shows that adaptive CD8+ T cell activation induces expression of the innate receptor NKG2D for the elimination of MHC class I–deficient tumors.
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Rudd, C.E. CD8+ T cell killing of MHC class I–deficient tumors. Nat Cancer 4, 1214–1216 (2023). https://doi.org/10.1038/s43018-023-00606-y
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DOI: https://doi.org/10.1038/s43018-023-00606-y