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Master kinases extracted from proteogenomic networks in glioblastoma drive cancer subtypes

Using an unbiased algorithm based on kinase–phosphorylation site interactions that is applicable to any proteomic dataset, we identified and experimentally validated two protein kinases (PKCδ and DNA-PKcs) as the master kinases that drive two functional subtypes of glioblastoma multiforme and are potential therapeutic targets of other cancer subtypes.

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Fig. 1: The SPHINKS kinase–phosphosites interactome of GBM.


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This is a summary of: Migliozzi, S. et al. Integrative multi-omics networks identify PKCδ and DNA-PK as master kinases of glioblastoma subtypes and guide targeted cancer therapy. Nat. Cancer (2023).

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Master kinases extracted from proteogenomic networks in glioblastoma drive cancer subtypes. Nat Cancer 4, 159–160 (2023).

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