Using an unbiased algorithm based on kinase–phosphorylation site interactions that is applicable to any proteomic dataset, we identified and experimentally validated two protein kinases (PKCδ and DNA-PKcs) as the master kinases that drive two functional subtypes of glioblastoma multiforme and are potential therapeutic targets of other cancer subtypes.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Garofano, L. et al. Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities. Nat. Cancer 2, 141–156 (2021). This paper introduces the single-cell and biological pathway-based classification of GBM in four subtypes.
Wang, L. B. et al. Proteogenomic and metabolomic characterization of human glioblastoma. Cancer Cell 39, 509–528 (2021). This paper reports the multi-omics profiling of 99 treatment-naive GBMs from the CPTAC using 10 different molecular platforms.
Gonzalez Castro, L. N., Tirosh, I. & Suva, M. L. Decoding cancer biology one cell at a time. Cancer Discov. 11, 960–970 (2021). A review article of single-cell resolution studies across human tumor types and intratumor heterogeneity.
Varn, F. S. et al. Glioma progression is shaped by genetic evolution and microenvironment interactions. Cell 185, 2184–2199 (2022). This paper reports the transcriptomic results of temporally separated pairs of IDH-mutant and IDH-wild-type gliomas from the Glioma Longitudinal AnalySiS (GLASS) consortium.
Carro, M. S. et al. The transcriptional network for mesenchymal transformation of brain tumours. Nature 463, 318–325 (2010). This paper reports the unbiased interrogation of glioma-specific regulatory networks and the experimental validation of two master regulators of the mesenchymal phenotype of malignant glioma.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Migliozzi, S. et al. Integrative multi-omics networks identify PKCδ and DNA-PK as master kinases of glioblastoma subtypes and guide targeted cancer therapy. Nat. Cancer https://doi.org/10.1038/s43018-022-00510-x (2023).
Rights and permissions
About this article
Cite this article
Master kinases extracted from proteogenomic networks in glioblastoma drive cancer subtypes. Nat Cancer 4, 159–160 (2023). https://doi.org/10.1038/s43018-022-00511-w