Using an unbiased algorithm based on kinase–phosphorylation site interactions that is applicable to any proteomic dataset, we identified and experimentally validated two protein kinases (PKCδ and DNA-PKcs) as the master kinases that drive two functional subtypes of glioblastoma multiforme and are potential therapeutic targets of other cancer subtypes.
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References
Garofano, L. et al. Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities. Nat. Cancer 2, 141–156 (2021). This paper introduces the single-cell and biological pathway-based classification of GBM in four subtypes.
Wang, L. B. et al. Proteogenomic and metabolomic characterization of human glioblastoma. Cancer Cell 39, 509–528 (2021). This paper reports the multi-omics profiling of 99 treatment-naive GBMs from the CPTAC using 10 different molecular platforms.
Gonzalez Castro, L. N., Tirosh, I. & Suva, M. L. Decoding cancer biology one cell at a time. Cancer Discov. 11, 960–970 (2021). A review article of single-cell resolution studies across human tumor types and intratumor heterogeneity.
Varn, F. S. et al. Glioma progression is shaped by genetic evolution and microenvironment interactions. Cell 185, 2184–2199 (2022). This paper reports the transcriptomic results of temporally separated pairs of IDH-mutant and IDH-wild-type gliomas from the Glioma Longitudinal AnalySiS (GLASS) consortium.
Carro, M. S. et al. The transcriptional network for mesenchymal transformation of brain tumours. Nature 463, 318–325 (2010). This paper reports the unbiased interrogation of glioma-specific regulatory networks and the experimental validation of two master regulators of the mesenchymal phenotype of malignant glioma.
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This is a summary of: Migliozzi, S. et al. Integrative multi-omics networks identify PKCδ and DNA-PK as master kinases of glioblastoma subtypes and guide targeted cancer therapy. Nat. Cancer https://doi.org/10.1038/s43018-022-00510-x (2023).
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Master kinases extracted from proteogenomic networks in glioblastoma drive cancer subtypes. Nat Cancer 4, 159–160 (2023). https://doi.org/10.1038/s43018-022-00511-w
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DOI: https://doi.org/10.1038/s43018-022-00511-w
