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Cancer immunotherapy

Keeping track of the T cells that matter

The identification of tumor-reactive T cells using phenotypic markers is now well established in treatment-naive tumors. It is unclear, however, whether these markers can also be useful after immune checkpoint blockade (ICB). A new study finds that CXCL13 expression robustly identifies tumor-reactive T cells before and after ICB and is associated with treatment response.

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Fig. 1: CXCL13+ tumor-reactive CD8+ T cells in human cancers at baseline and following immune checkpoint blockade.

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Correspondence to Daniela S. Thommen.

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Kaptein, P., Thommen, D.S. Keeping track of the T cells that matter. Nat Cancer 3, 1015–1017 (2022). https://doi.org/10.1038/s43018-022-00432-8

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