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Cancer immunotherapy

Keeping track of the T cells that matter

The identification of tumor-reactive T cells using phenotypic markers is now well established in treatment-naive tumors. It is unclear, however, whether these markers can also be useful after immune checkpoint blockade (ICB). A new study finds that CXCL13 expression robustly identifies tumor-reactive T cells before and after ICB and is associated with treatment response.

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Fig. 1: CXCL13+ tumor-reactive CD8+ T cells in human cancers at baseline and following immune checkpoint blockade.


  1. Liu, B., Zhang, Y., Wang, D., Hu, X. & Zhang, Z. Nat. Cancer (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Gros, A. et al. Nat. Med. 22, 433–438 (2016).

    Article  CAS  Google Scholar 

  3. Scheper, W. et al. Nat. Med. 25, 89–94 (2019).

    Article  CAS  Google Scholar 

  4. Tran, K. Q. et al. J. Immunother. 31, 742–751 (2008).

    Article  CAS  Google Scholar 

  5. Simoni, Y. et al. Nature 557, 575–579 (2018).

    Article  CAS  Google Scholar 

  6. Duhen, T. et al. Nat. Commun. 9, 2724 (2018).

    Article  Google Scholar 

  7. Thommen, D. S. et al. Nat. Med. 24, 994–1004 (2018).

    Article  CAS  Google Scholar 

  8. Oliveira, G. et al. Nature 596, 119–125 (2021).

    Article  CAS  Google Scholar 

  9. Lowery, F. J. et al. Science 375, 877–884 (2022).

    Article  CAS  Google Scholar 

  10. Caushi, J. X. et al. Nature 596, 126–132 (2021).

    Article  CAS  Google Scholar 

  11. Litchfield, K. et al. Cell 184, 596–614.e14 (2021).

    Article  CAS  Google Scholar 

  12. Zhang, Y. et al. Cancer Cell 39, 1578–1593.e8 (2021).

    Article  CAS  Google Scholar 

  13. van der Leun, A. M., Thommen, D. S. & Schumacher, T. N. Nat. Rev. Cancer 20, 218–232 (2020).

    Article  Google Scholar 

  14. Garcia-Diaz, A. et al. Cell Rep. 19, 1189–1201 (2017).

    Article  CAS  Google Scholar 

  15. David, J. M. et al. Oncoimmunology 6, e1349589 (2017).

    Article  Google Scholar 

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Correspondence to Daniela S. Thommen.

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Kaptein, P., Thommen, D.S. Keeping track of the T cells that matter. Nat Cancer 3, 1015–1017 (2022).

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