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IMMUNOTHERAPY

Checking ovarian reserves after checkpoint blockade

Immune checkpoint inhibitors (ICIs) are effective for many cancers but can be limited by inflammatory toxicities. Little is known about how ICIs affect the reproductive system. New research in animal models with and without tumours demonstrates that ovarian reserves are depleted in mice treated with ICIs, which may influence fertility.

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Fig. 1: Ovaries contain a small number of TRM and TEM cells at baseline.

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Correspondence to Michael Dougan.

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Competing interests

M.D. has research funding from Novartis and Eli Lilly and Company; has received consulting fees from Tillotts Pharma, ORIC Pharmaceuticals, Partner Therapeutics, SQZ Biotech, AzurRx, Eli Lilly and Company, Mallinckrodt Pharmaceuticals, Aditum and Moderna; and is a member of the scientific advisory board for Neoleukin Therapeutics. S.A.R. declares no competing interests.

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Roberts, S.A., Dougan, M. Checking ovarian reserves after checkpoint blockade. Nat Cancer 3, 907–908 (2022). https://doi.org/10.1038/s43018-022-00422-w

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