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CANCER IMMUNOTHERAPY

PAK4 as a cancer immune-evasion target

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Immunotherapy resistance is associated with poor T cell infiltration into tumors. Tumor-cell-intrinsic oncogenic events that contribute to this defect include Wnt–β-catenin activation. PAK4 is now identified as an upstream modulator of this pathway, thus suggesting the potential of enhancing the efficacy of immunotherapy by targeting this druggable kinase.

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Fig. 1: The role of PAK4 in tumor-intrinsic Wnt–β-catenin signaling and the anti-tumor immune response.

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Correspondence to Thomas F. Gajewski.

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The authors declare no competing interests.

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Gajewski, T.F., Fessler, J. PAK4 as a cancer immune-evasion target. Nat Cancer 1, 18–19 (2020). https://doi.org/10.1038/s43018-019-0012-z

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