Abstract
Skin-interfaced electronics is gradually changing medical practices by enabling continuous and non-invasive tracking of physiological and biochemical information. With the rise of big data and digital medicine, next-generation electronic skin (e-skin) will be able to use artificial intelligence (AI) to optimize its design as well as uncover user-personalized health profiles. Recent multimodal e-skin platforms have already used machine learning algorithms for autonomous data analytics. Unfortunately, there is a lack of appropriate AI protocols and guidelines for e-skin devices, resulting in overly complex models and non-reproducible conclusions for simple applications. This Review aims to present AI technologies in e-skin hardware and assess their potential for new inspired integrated platform solutions. We outline recent breakthroughs in AI strategies and their applications in engineering e-skins as well as understanding health information collected by e-skins, highlighting the transformative deployment of AI in robotics, prosthetics, virtual reality and personalized healthcare. We also discuss the challenges and prospects of AI-powered e-skins as well as predictions for the future trajectory of smart e-skins.
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References
Kim, D.-H. et al. Epidermal electronics. Science 333, 838–843 (2011).
Yu, Y. et al. All-printed soft human–machine interface for robotic physicochemical sensing. Sci. Robot. 7, eabn0495 (2022).
Shirzaei Sani, E. et al. A stretchable wireless wearable bioelectronic system for multiplexed monitoring and combination treatment of infected chronic wounds. Sci. Adv. 9, eadf7388 (2023).
Gao, W. et al. Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis. Nature 529, 509–514 (2016).
Shi, X. et al. Large-area display textiles integrated with functional systems. Nature 591, 240–245 (2021).
Lochner, C. M., Khan, Y., Pierre, A. & Arias, A. C. All-organic optoelectronic sensor for pulse oximetry. Nat. Commun. 5, 5745 (2014).
Nguyen, P. Q. et al. Wearable materials with embedded synthetic biology sensors for biomolecule detection. Nat. Biotechnol. 39, 1366–1374 (2021).
Zhang, Z. et al. Deep learning-enabled triboelectric smart socks for IoT-based gait analysis and VR applications. npj Flex. Electron. 4, 1–12 (2020).
Hammock, M. L., Chortos, A., Tee, B. C.-K., Tok, J. B.-H. & Bao, Z. The evolution of electronic skin (e-skin): a brief history, design considerations, and recent progress. Adv. Mater. 25, 5997–6038 (2013).
Wang, M. et al. A wearable electrochemical biosensor for the monitoring of metabolites and nutrients. Nat. Biomed. Eng. 6, 1225–1235 (2022).
Yu, X. et al. Skin-integrated wireless haptic interfaces for virtual and augmented reality. Nature 575, 473–479 (2019).
Jung, Y. H. et al. A wireless haptic interface for programmable patterns of touch across large areas of the skin. Nat. Electron. 5, 374–385 (2022).
Yang, Y. et al. A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat. Nat. Biotechnol. 38, 217–224 (2020).
Yang, Y. et al. Artificial intelligence-enabled detection and assessment of Parkinson’s disease using nocturnal breathing signals. Nat. Med. 28, 2207–2215 (2022).
Mishra, T. et al. Pre-symptomatic detection of COVID-19 from smartwatch data. Nat. Biomed. Eng. 4, 1208–1220 (2020).
Quer, G. et al. Wearable sensor data and self-reported symptoms for COVID-19 detection. Nat. Med. 27, 73–77 (2021).
Xiao, X., Fang, Y., Xiao, X., Xu, J. & Chen, J. Machine-learning-aided self-powered assistive physical therapy devices. ACS Nano 15, 18633–18646 (2021).
Ngiam, K. Y. & Khor, I. W. Big data and machine learning algorithms for health-care delivery. Lancet Oncol. 20, e262–e273 (2019).
Elmarakeby, H. A. et al. Biologically informed deep neural network for prostate cancer discovery. Nature 598, 348–352 (2021).
Haug, C. J. & Drazen, J. M. Artificial intelligence and machine learning in clinical medicine, 2023. N. Engl. J. Med. 388, 1201–1208 (2023).
Brownstein, J. S., Rader, B., Astley, C. M. & Tian, H. Advances in artificial intelligence for infectious-disease surveillance. N. Engl. J. Med. 388, 1597–1607 (2023).
Ates, H. C. et al. End-to-end design of wearable sensors. Nat. Rev. Mater. 7, 887–907 (2022).
Acosta, J. N., Falcone, G. J., Rajpurkar, P. & Topol, E. J. Multimodal biomedical AI. Nat. Med. 28, 1773–1784 (2022).
Yamada, T. et al. A stretchable carbon nanotube strain sensor for human-motion detection. Nat. Nanotechnol. 6, 296–301 (2011).
You, I. et al. Artificial multimodal receptors based on ion relaxation dynamics. Science 370, 961–965 (2020).
Lee, S. et al. A transparent bending-insensitive pressure sensor. Nat. Nanotechnol. 11, 472–478 (2016).
Wang, S. et al. Skin electronics from scalable fabrication of an intrinsically stretchable transistor array. Nature 555, 83–88 (2018).
Wang, C. et al. User-interactive electronic skin for instantaneous pressure visualization. Nat. Mater. 12, 899–904 (2013).
Sun, H., Kuchenbecker, K. J. & Martius, G. A soft thumb-sized vision-based sensor with accurate all-round force perception. Nat. Mach. Intell. 4, 135–145 (2022).
Tee, B. C.-K. et al. A skin-inspired organic digital mechanoreceptor. Science 350, 313–316 (2015).
Chun, S. et al. An artificial neural tactile sensing system. Nat. Electron. 4, 429–438 (2021).
Huang, Y.-C. et al. Sensitive pressure sensors based on conductive microstructured air-gap gates and two-dimensional semiconductor transistors. Nat. Electron. 3, 59–69 (2020).
Wang, C. et al. Bioadhesive ultrasound for long-term continuous imaging of diverse organs. Science 377, 517–523 (2022).
Hu, H. et al. A wearable cardiac ultrasound imager. Nature 613, 667–675 (2023).
Gao, X. et al. A photoacoustic patch for three-dimensional imaging of hemoglobin and core temperature. Nat. Commun. 13, 7757 (2022).
Han, S. et al. Battery-free, wireless sensors for full-body pressure and temperature mapping. Sci. Transl. Med. 10, eaan4950 (2018).
Eggenberger, P. et al. Prediction of core body temperature based on skin temperature, heat flux, and heart rate under different exercise and clothing conditions in the heat in young adult males. Front. Physiol. 9, 1780 (2018).
Yu, Y. et al. Biofuel-powered soft electronic skin with multiplexed and wireless sensing for human-machine interfaces. Sci. Robot. 5, eaaz7946 (2020).
Sugiyama, M. et al. An ultraflexible organic differential amplifier for recording electrocardiograms. Nat. Electron. 2, 351–360 (2019).
Kim, M. K. et al. Flexible submental sensor patch with remote monitoring controls for management of oropharyngeal swallowing disorders. Sci. Adv. 5, eaay3210 (2019).
Kwon, Y.-T. et al. Printed, wireless, soft bioelectronics and deep learning algorithm for smart human–machine interfaces. ACS Appl. Mater. Interfaces 12, 49398–49406 (2020).
Tian, L. et al. Large-area MRI-compatible epidermal electronic interfaces for prosthetic control and cognitive monitoring. Nat. Biomed. Eng. 3, 194–205 (2019).
Mahmood, M. et al. Fully portable and wireless universal brain–machine interfaces enabled by flexible scalp electronics and deep learning algorithm. Nat. Mach. Intell. 1, 412–422 (2019).
Emaminejad, S. et al. Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform. Proc. Natl Acad. Sci. USA 114, 4625–4630 (2017).
Li, J. et al. A tissue-like neurotransmitter sensor for the brain and gut. Nature 606, 94–101 (2022).
Tu, J. et al. A wireless patch for the monitoring of C-reactive protein in sweat. Nat. Biomed. Eng. 7, 1293–1306 (2023).
Sempionatto, J. R. et al. An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers. Nat. Biomed. Eng. 5, 737–748 (2021).
Arakawa, T. et al. Mouthguard biosensor with telemetry system for monitoring of saliva glucose: a novel cavitas sensor. Biosens. Bioelectron. 84, 106–111 (2016).
Chen, Y. et al. Skin-like biosensor system via electrochemical channels for noninvasive blood glucose monitoring. Sci. Adv. 3, e1701629 (2017).
Min, J. et al. Skin-interfaced wearable sweat sensors for precision medicine. Chem. Rev. 123, 5049–5138 (2023).
Torrente-RodrĂguez, R. M. et al. Investigation of cortisol dynamics in human sweat using a graphene-based wireless mHealth system. Matter 2, 921–937 (2020).
Teymourian, H. et al. Wearable electrochemical sensors for the monitoring and screening of drugs. ACS Sens. 5, 2679–2700 (2020).
Lin, S. et al. Wearable microneedle-based electrochemical aptamer biosensing for precision dosing of drugs with narrow therapeutic windows. Sci. Adv. 8, eabq4539 (2022).
Tai, L.-C. et al. Wearable sweat band for noninvasive levodopa monitoring. Nano Lett. 19, 6346–6351 (2019).
Nyein, H. Y. Y. et al. A wearable patch for continuous analysis of thermoregulatory sweat at rest. Nat. Commun. 12, 1823 (2021).
Tehrani, F. et al. An integrated wearable microneedle array for the continuous monitoring of multiple biomarkers in interstitial fluid. Nat. Biomed. Eng. 6, 1214–1224 (2022).
Song, Y. et al. 3D-printed epifluidic electronic skin for machine learning–powered multimodal health surveillance. Sci. Adv. 9, eadi6492 (2023).
Tai, L.-C. et al. Methylxanthine drug monitoring with wearable sweat sensors. Adv. Mater. 30, 1707442 (2018).
Gao, W. et al. Wearable microsensor array for multiplexed heavy metal monitoring of body fluids. ACS Sens. 1, 866–874 (2016).
Kintz, P., Tracqui, A., Mangin, P. & Edel, Y. Sweat testing in opioid users with a sweat patch. J. Anal. Toxicol. 20, 393–397 (1996).
Tai, L.-C. et al. Nicotine monitoring with a wearable sweat band. ACS Sens. 5, 1831–1837 (2020).
Shirasu, M. & Touhara, K. The scent of disease: volatile organic compounds of the human body related to disease and disorder. J. Biochem. 150, 257–266 (2011).
Saasa, V., Beukes, M., Lemmer, Y. & Mwakikunga, B. Blood ketone bodies and breath acetone analysis and their correlations in type 2 diabetes mellitus. Diagnostics 9, 224 (2019).
Risby, T. H. & Solga, S. F. Current status of clinical breath analysis. Appl. Phys. B 85, 421–426 (2006).
Jalal, A. H. et al. Prospects and challenges of volatile organic compound sensors in human healthcare. ACS Sens. 3, 1246–1263 (2018).
Capman, N. S. S. et al. Machine learning-based rapid detection of volatile organic compounds in a graphene electronic nose. ACS Nano 16, 19567–19583 (2022).
Ozer, E. et al. A hardwired machine learning processing engine fabricated with submicron metal-oxide thin-film transistors on a flexible substrate. Nat. Electron. 3, 419–425 (2020).
Jirayupat, C. et al. Breath odor-based individual authentication by an artificial olfactory sensor system and machine learning. Chem. Commun. 58, 6377–6380 (2022).
Grell, M. et al. Point-of-use sensors and machine learning enable low-cost determination of soil nitrogen. Nat. Food 2, 981–989 (2021).
Guo, L. et al. Portable food-freshness prediction platform based on colorimetric barcode combinatorics and deep convolutional neural networks. Adv. Mater. 32, 2004805 (2020).
Hippalgaonkar, K. et al. Knowledge-integrated machine learning for materials: lessons from gameplaying and robotics. Nat. Rev. Mater. 8, 241–260 (2023).
Batra, R., Song, L. & Ramprasad, R. Emerging materials intelligence ecosystems propelled by machine learning. Nat. Rev. Mater. 6, 655–678 (2021).
Pyun, K. R., Rogers, J. A. & Ko, S. H. Materials and devices for immersive virtual reality. Nat. Rev. Mater. 7, 841–843 (2022).
Libanori, A., Chen, G., Zhao, X., Zhou, Y. & Chen, J. Smart textiles for personalized healthcare. Nat. Electron. 5, 142–156 (2022).
Matsuhisa, N., Chen, X., Bao, Z. & Someya, T. Materials and structural designs of stretchable conductors. Chem. Soc. Rev. 48, 2946–2966 (2019).
Xu, S. et al. Soft microfluidic assemblies of sensors, circuits, and radios for the skin. Science 344, 70–74 (2014).
Yuk, H. et al. Dry double-sided tape for adhesion of wet tissues and devices. Nature 575, 169–174 (2019).
Mukasa, D. et al. A computationally assisted approach for designing wearable biosensors toward non-invasive personalized molecular analysis. Adv. Mater. 35, 2212161 (2023).
Hart, G. L. W., Mueller, T., Toher, C. & Curtarolo, S. Machine learning for alloys. Nat. Rev. Mater. 6, 730–755 (2021).
Tao, H. et al. Nanoparticle synthesis assisted by machine learning. Nat. Rev. Mater. 6, 701–716 (2021).
Ding, W.-L. et al. Accelerating evaluation of the mobility of ionic liquid-modulated PEDOT flexible electronics using machine learning. J. Mater. Chem. A 9, 25547–25557 (2021).
Kim, E. et al. Materials synthesis insights from scientific literature via text extraction and machine learning. Chem. Mater. 29, 9436–9444 (2017).
Kim, E. et al. Inorganic materials synthesis planning with literature-trained neural networks. J. Chem. Inf. Model. 60, 1194–1201 (2020).
Abbasi Shirsavar, M. et al. Machine learning-assisted e-jet printing for manufacturing of organic flexible electronics. Biosens. Bioelectron. 212, 114418 (2022).
Wang, H. et al. GCN-RL circuit designer: transferable transistor sizing with graph neural networks and reinforcement learning. In 2020 57th ACM/IEEE Design Automation Conference https://doi.org/10.1109/DAC18072.2020.9218757 (IEEE, 2020).
Liu, S. et al. Conformability of flexible sheets on spherical surfaces. Sci. Adv. 9, eadf2709 (2023).
Hanakata, P. Z., Cubuk, E. D., Campbell, D. K. & Park, H. S. Accelerated search and design of stretchable graphene kirigami using machine learning. Phys. Rev. Lett. 121, 255304 (2018).
Forte, A. E. et al. Inverse design of inflatable soft membranes through machine learning. Adv. Funct. Mater. 32, 2111610 (2022).
Irwin, B. W. J., Levell, J. R., Whitehead, T. M., Segall, M. D. & Conduit, G. J. Practical applications of deep learning to impute heterogeneous drug discovery data. J. Chem. Inf. Model. 60, 2848–2857 (2020).
Jia, X. et al. Anthropogenic biases in chemical reaction data hinder exploratory inorganic synthesis. Nature 573, 251–255 (2019).
Ballard, Z., Brown, C., Madni, A. M. & Ozcan, A. Machine learning and computation-enabled intelligent sensor design. Nat. Mach. Intell. 3, 556–565 (2021).
Rasti-Meymandi, A. & Ghaffari, A. A deep learning-based framework for ECG signal denoising based on stacked cardiac cycle tensor. Biomed. Signal Process. Control 71, 103275 (2022).
Holobar, A. & Farina, D. Noninvasive neural interfacing with wearable muscle sensors: combining convolutive blind source separation methods and deep learning techniques for neural decoding. IEEE Signal Process Mag. 38, 103–118 (2021).
Stalin, S. et al. A machine learning-based big EEG data artifact detection and wavelet-based removal: an empirical approach. Math. Probl. Eng. 2021, e2942808 (2021).
Tang, W. et al. Microheater integrated nanotube array gas sensor for parts-per-trillion level gas detection and single sensor-based gas discrimination. ACS Nano 16, 10968–10978 (2022).
Bian, L., Wang, Z., White, D. L. & Star, A. Machine learning-assisted calibration of Hg2+ sensors based on carbon nanotube field-effect transistors. Biosens. Bioelectron. 180, 113085 (2021).
Zhu, C. et al. Stretchable temperature-sensing circuits with strain suppression based on carbon nanotube transistors. Nat. Electron. 1, 183–190 (2018).
Song, J.-K. et al. Stretchable colour-sensitive quantum dot nanocomposites for shape-tunable multiplexed phototransistor arrays. Nat. Nanotechnol. 17, 849–856 (2022).
Shim, H. et al. An elastic and reconfigurable synaptic transistor based on a stretchable bilayer semiconductor. Nat. Electron. 5, 660–671 (2022).
Yu, F. et al. Brain-inspired multimodal hybrid neural network for robot place recognition. Sci. Robot. 8, eabm6996 (2023).
Almalioglu, Y., Turan, M., Trigoni, N. & Markham, A. Deep learning-based robust positioning for all-weather autonomous driving. Nat. Mach. Intell. 4, 749–760 (2022).
Moin, A. et al. A wearable biosensing system with in-sensor adaptive machine learning for hand gesture recognition. Nat. Electron. 4, 54–63 (2021).
Kim, K. K. et al. A substrate-less nanomesh receptor with meta-learning for rapid hand task recognition. Nat. Electron. 6, 64–75 (2023).
Li, G., Liu, S., Wang, L. & Zhu, R. Skin-inspired quadruple tactile sensors integrated on a robot hand enable object recognition. Sci. Robot. 5, eabc8134 (2020).
Sundaram, S. et al. Learning the signatures of the human grasp using a scalable tactile glove. Nature 569, 698–702 (2019).
Luo, Y. et al. Learning human–environment interactions using conformal tactile textiles. Nat. Electron. 4, 193–201 (2021).
Wang, M. et al. Gesture recognition using a bioinspired learning architecture that integrates visual data with somatosensory data from stretchable sensors. Nat. Electron. 3, 563–570 (2020).
Yao, H. et al. Near-hysteresis-free soft tactile electronic skins for wearables and reliable machine learning. Proc. Natl Acad. Sci. USA 117, 25352–25359 (2020).
Qu, X. et al. Artificial tactile perception smart finger for material identification based on triboelectric sensing. Sci. Adv. 8, eabq2521 (2022).
Gu, G. et al. A soft neuroprosthetic hand providing simultaneous myoelectric control and tactile feedback. Nat. Biomed. Eng. 7, 589–598 (2021).
Sun, T. et al. Decoding of facial strains via conformable piezoelectric interfaces. Nat. Biomed. Eng. 4, 954–972 (2020).
Zhou, Z. et al. Sign-to-speech translation using machine-learning-assisted stretchable sensor arrays. Nat. Electron. 3, 571–578 (2020).
Slade, P., Kochenderfer, M. J., Delp, S. L. & Collins, S. H. Personalizing exoskeleton assistance while walking in the real world. Nature 610, 277–282 (2022).
Slade, P., Tambe, A. & Kochenderfer, M. J. Multimodal sensing and intuitive steering assistance improve navigation and mobility for people with impaired vision. Sci. Robot. 6, eabg6594 (2021).
Ponnan, S., Theivadas, J. R., Vs, H. & Einarson, D. Driver monitoring and passenger interaction system using wearable device in intelligent vehicle. Comput. Electr. Eng. 103, 108323 (2022).
Shao, H. et al. High-performance voice recognition based on piezoelectric polyacrylonitrile banofibers. Adv. Electron. Mater. 7, 2100206 (2021).
Jeong, H. et al. Closed-loop network of skin-interfaced wireless devices for quantifying vocal fatigue and providing user feedback. Proc. Natl Acad. Sci. USA 120, e2219394120 (2023).
Lin, Z. et al. A personalized acoustic interface for wearable human–machine interaction. Adv. Funct. Mater. 32, 2109430 (2022).
Gong, S. et al. Hierarchically resistive skins as specific and multimetric on-throat wearable biosensors. Nat. Nanotechnol. 18, 889–897 (2023).
Wang, H. S. et al. Biomimetic and flexible piezoelectric mobile acoustic sensors with multiresonant ultrathin structures for machine learning biometrics. Sci. Adv. 7, eabe5683 (2021).
Yang, Q. et al. Mixed-modality speech recognition and interaction using a wearable artificial throat. Nat. Mach. Intell. 5, 169–180 (2023).
Zhang, Z. et al. Active mechanical haptics with high-fidelity perceptions for immersive virtual reality. Nat. Mach. Intell. 5, 643–655 (2023).
Liu, Y. et al. Electronic skin as wireless human-machine interfaces for robotic VR. Sci. Adv. 8, eabl6700 (2022).
Yao, K. et al. Encoding of tactile information in hand via skin-integrated wireless haptic interface. Nat. Mach. Intell. 4, 893–903 (2022).
Wen, F. et al. Machine learning glove using self-powered conductive superhydrophobic triboelectric textile for gesture recognition in VR/AR applications. Adv. Sci. 7, 2000261 (2020).
Mennel, L. et al. Ultrafast machine vision with 2D material neural network image sensors. Nature 579, 62–66 (2020).
Liu, Y. et al. Soft, miniaturized, wireless olfactory interface for virtual reality. Nat. Commun. 14, 2297 (2023).
Yu, K.-H., Beam, A. L. & Kohane, I. S. Artificial intelligence in healthcare. Nat. Biomed. Eng. 2, 719–731 (2018).
Hannun, A. Y. et al. Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network. Nat. Med. 25, 65–69 (2019).
Attia, Z. I. et al. Screening for cardiac contractile dysfunction using an artificial intelligence-enabled electrocardiogram. Nat. Med. 25, 70–74 (2019).
Krittanawong, C. et al. Integration of novel monitoring devices with machine learning technology for scalable cardiovascular management. Nat. Rev. Cardiol. 18, 75–91 (2021).
Fang, Y. et al. Ambulatory cardiovascular monitoring via a machine-learning-assisted textile triboelectric sensor. Adv. Mater. 33, 2104178 (2021).
Kireev, D. et al. Continuous cuffless monitoring of arterial blood pressure via graphene bioimpedance tattoos. Nat. Nanotechnol. 17, 864–870 (2022).
Choi, J., Ahmed, B. & Gutierrez-Osuna, R. Development and evaluation of an ambulatory stress monitor based on wearable sensors. IEEE Trans. Inf. Technol. Biomed. 16, 279–286 (2012).
Gjoreski, M., Luštrek, M., Gams, M. & Gjoreski, H. Monitoring stress with a wrist device using context. J. Biomed. Inform. 73, 159–170 (2017).
Hwang, B. et al. Deep ECGNet: an optimal deep learning framework for monitoring mental stress using ultra short-term ECG signals. Telemed. eHealth 24, 753–772 (2018).
Zeng, Z. et al. Nonintrusive monitoring of mental fatigue status using epidermal electronic systems and machine-learning algorithms. ACS Sens. 5, 1305–1313 (2020).
Gholami, M., Napier, C., Patiño, A. G., Cuthbert, T. J. & Menon, C. Fatigue monitoring in running using flexible textile wearable sensors. Sensors 20, 5573 (2020).
Chaabene, S. et al. Convolutional neural network for drowsiness detection using EEG signals. Sensors 21, 1734 (2021).
Parlak, O., Keene, S. T., Marais, A., Curto, V. F. & Salleo, A. Molecularly selective nanoporous membrane-based wearable organic electrochemical device for noninvasive cortisol sensing. Sci. Adv. 4, eaar2904 (2018).
Shah, R. V. et al. Personalized machine learning of depressed mood using wearables. Transl. Psychiatry 11, 338 (2021).
Mastoras, R.-E. et al. Touchscreen typing pattern analysis for remote detection of the depressive tendency. Sci. Rep. 9, 13414 (2019).
Sempionatto, J. R., Lasalde-RamĂrez, J. A., Mahato, K., Wang, J. & Gao, W. Wearable chemical sensors for biomarker discovery in the omics era. Nat. Rev. Chem. 6, 899–915 (2022).
Baik, S. et al. Diving beetle-like miniaturized plungers with reversible, rapid biofluid capturing for machine learning-based care of skin disease. Sci. Adv. 7, eabf5695 (2021).
O’Brien, M. K. et al. Advanced machine learning tools to monitor biomarkers of dysphagia: a wearable sensor proof-of-concept study. Digit. Biomark. 5, 167–175 (2021).
Meisel, C. et al. Machine learning from wristband sensor data for wearable, noninvasive seizure forecasting. Epilepsia 61, 2653–2666 (2020).
Ni, X. et al. Automated, multiparametric monitoring of respiratory biomarkers and vital signs in clinical and home settings for COVID-19 patients. Proc. Natl Acad. Sci. USA 118, e2026610118 (2021).
Yang, C. et al. A machine-learning-enhanced simultaneous and multimodal sensor based on moist-electric powered graphene oxide. Adv. Mater. 34, 2205249 (2022).
Miljković, F. et al. Machine learning models for human in vivo pharmacokinetic parameters with in-house validation. Mol. Pharm. 18, 4520–4530 (2021).
Keutzer, L. et al. Machine learning and pharmacometrics for prediction of pharmacokinetic data: differences, similarities and challenges illustrated with rifampicin. Pharmaceutics 14, 1530 (2022).
Khajuria, R. & Sarwar, A. in Recent Innovations in Computing Lecture Notes in Electrical Engineering Vol. 832 (eds Singh, P. K. et al.) 179–188 (Springer, 2022).
Li, H., Wu, J., Gao, Y. & Shi, Y. Examining individuals’ adoption of healthcare wearable devices: an empirical study from privacy calculus perspective. Int. J. Med. Inform. 88, 8–17 (2016).
Lee, P., Bubeck, S. & Petro, J. Benefits, limits, and risks of GPT-4 as an AI chatbot for medicine. N. Engl. J. Med. 388, 1233–1239 (2023).
Lundberg, S. M. et al. From local explanations to global understanding with explainable AI for trees. Nat. Mach. Intell. 2, 56–67 (2020).
Buergel, T. et al. Metabolomic profiles predict individual multidisease outcomes. Nat. Med. 28, 2309–2320 (2022).
Park, S. et al. Self-powered ultra-flexible electronics via nano-grating-patterned organic photovoltaics. Nature 561, 516–521 (2018).
Han, X. et al. Deep learning models for electrocardiograms are susceptible to adversarial attack. Nat. Med. 26, 360–363 (2020).
Massari, L. et al. Functional mimicry of Ruffini receptors with fibre Bragg gratings and deep neural networks enables a bio-inspired large-area tactile-sensitive skin. Nat. Mach. Intell. 4, 425–435 (2022).
Yan, Y. et al. Soft magnetic skin for super-resolution tactile sensing with force self-decoupling. Sci. Robot. 6, eabc8801 (2021).
Acknowledgements
This work was funded by Office of Naval Research grants N00014-21-1-2483 and N00014-21-1-2845, Army Research Office grant W911NF-23-1-0041, National Institutes of Health grants R01HL155815 and R21DK13266, National Science Foundation grant 2145802 and National Academy of Medicine Catalyst Award. C.X. was supported by Amazon AI4Science Fellowship.
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Xu, C., Solomon, S.A. & Gao, W. Artificial intelligence-powered electronic skin. Nat Mach Intell 5, 1344–1355 (2023). https://doi.org/10.1038/s42256-023-00760-z
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DOI: https://doi.org/10.1038/s42256-023-00760-z