Abstract
Regaining fine motor skills (FMSs; that is, the ability to make precise and coordinated movements of fingers) is the ultimate goal of hand rehabilitation. Although robotic-assisted technologies have been widely explored to help patients with simple hand activities, existing rehabilitation gloves still lack sensory feedback for closed-loop control or involve bulky external hardware, incapable of providing precise FMSs rehabilitation portably. Here we develop a soft rehabilitation glove that can accomplish diverse FMSs by integrating 15 bending sensors and 10 shape-memory-alloy (SMA) actuators. Three joint angles of each finger can be precisely sensed and thus are fed to the control system to actuate SMAs in a closed-loop manner. A touchable human–machine interface is also integrated to provide facile interaction for multi-modal rehabilitation exercises. Weighing only 0.49 kg, our soft glove has high portability, allowing for repetitive hand rehabilitation as needed. We validate that our glove can assist an individual with hand impairments after a stroke to realize a set of single and complex FMS rehabilitation exercises and to complete some activities of daily living.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Data availability
The authors declare that the main data supporting the findings of this study are available within the article and its Supplementary Information files. Other data, if needed, can be available upon request.
Code availability
All the relevant codes are available at https://github.com/weibayang/rehabilitation_glove (ref. 65).
References
Cao, D. et al. Efficacy and safety of manual acupuncture for the treatment of upper limb motor dysfunction after stroke: protocol for a systematic review and meta-analysis. PLoS ONE 16, e0258921 (2021).
Sobinov, A. R. & Bensmaia, S. J. The neural mechanisms of manual dexterity. Nat. Rev. Neurosci. 22, 741–757 (2021).
Yavuzer, G. et al. Mirror therapy improves hand function in subacute stroke: a randomized controlled trial. Arch. Phys. Med. Rehabil. 89, 393–398 (2008).
Pereira, M. F., Prahm, C., Kolbenschlag, J., Oliveira, E. & Rodrigues, N. F. Application of AR and VR in hand rehabilitation: a systematic review. J. Biomed. Inform. 111, 103584 (2020).
Draganski, B. et al. Neuroplasticity: changes in grey matter induced by training. Nature 427, 311–312 (2004).
Harvey, R. L. Improving poststroke recovery: neuroplasticity and task-oriented training. Curr. Treat. Options Cardiovasc. Med. 11, 251–259 (2009).
Keller, J. L. et al. Thirty years of hand therapy: the 2014 practice analysis. J. Hand Ther. 29, 222–234 (2016).
Zollo, L., Accoto, D., Sterzi, S. & Guglielmelli, E. Springer Handbook of Medical Technology (eds Kramme, R., et al.) Ch. 42 (Springer, 2011).
van Stormbroek, K. & Buchanan, H. Novice therapists in a developing context: extending the reach of hand rehabilitation. Hand Ther. 22, 141–152 (2017).
Leonardis, D. et al. An EMG-controlled robotic hand exoskeleton for bilateral rehabilitation. IEEE Trans. Haptics 8, 140–151 (2015).
Yang, G. Z., Riener, R. & Dario, P. To integrate and to empower: robots for rehabilitation and assistance. Sci. Robot. 2, eaan5593 (2017).
Dupont, P. E. et al. A decade retrospective of medical robotics research from 2010 to 2020. Sci. Robot. 6, eabi8017 (2021).
Borboni, A., Mor, M. & Faglia, R. Gloreha—hand robotic rehabilitation: design, mechanical model, and experiments. J. Dyn. Syst. Meas. Control. 138, 111003 (2016).
Baniqued, P. D. E. et al. Brain–computer interface robotics for hand rehabilitation after stroke: a systematic review. J. Neuroeng. Rehabil. 18, 15 (2021).
Lum, P. S., Godfrey, S. B., Brokaw, E. B., Holley, R. J. & Nichols, D. Robotic approaches for rehabilitation of hand function after stroke. Am. J. Phys. Med. 91, S242–S254 (2012).
Torrisi, M. et al. Beyond motor recovery after stroke: the role of hand robotic rehabilitation plus virtual reality in improving cognitive function. J. Clin. Neurosci. 92, 11–16 (2021).
Noronha, B. & Accoto, D. Exoskeletal devices for hand assistance and rehabilitation: a comprehensive analysis of state-of-the-art technologies. IEEE Trans. Med. Robot. Bionics 3, 525–538 (2021).
Sandoval-Gonzalez, O. et al. Design and development of a Hand exoskeleton robot for active and passive rehabilitation. Int. J. Adv. Robot. Syst. 13, 1–12 (2016).
Lambercy, O. et al. A haptic knob for rehabilitation of hand function. IEEE Trans. Neural Syst. Rehabil. Eng. 15, 356–366 (2007).
Maciejasz, P., Eschweiler, J., Gerlach-Hahn, K., Jansen-Troy, A. & Leonhardt, S. A survey on robotic devices for upper limb rehabilitation. J. Neuroeng. Rehabil. 11, 3 (2014).
Laschi, C., Mazzolai, B. & Cianchetti, M. Soft robotics: technologies and systems pushing the boundaries of robot abilities. Sci. Robot. 1, eaah3690 (2016).
Gorissen, B. et al. Elastic inflatable actuators for soft robotic applications. Adv. Mater. 29, 1604977 (2017).
Yang, G. Z. et al. The grand challenges of science robotics. Sci. Robot. 3, eaar7650 (2018).
Shahid, T., Gouwanda, D., Nurzaman, S. G. & Gopalai, A. A. Moving toward soft robotics: a decade review of the design of hand exoskeletons. Biomimetics 3, 17 (2018).
Zhang, Y. & Lu, M. A review of recent advancements in soft and flexible robots for medical applications. Int. J. Med. Robotics. Comput. Assist. Surg. 16, e2096 (2020).
Gul, J. Z. et al. 3D printing for soft robotics—a review. Sci. Technol. Adv. Mater. 19, 243–262 (2018).
Sanchez, V., Walsh, C. J. & Wood, R. J. Textile technology for soft robotic and autonomous garments. Adv. Funct. Mater. 31, 2008278 (2021).
Polygerinos, P., Wang, Z., Galloway, K. C., Wood, R. J. & Walsh, C. J. Soft robotic glove for combined assistance and at-home rehabilitation. Rob. Auton. Syst. 73, 135–143 (2015).
Yap, H. K. et al. A fully fabric-based bidirectional soft robotic glove for assistance and rehabilitation of hand impaired patients. IEEE Robot. Autom. Lett. 2, 1383–1390 (2017).
Wang, J., Fei, Y. & Pang, W. Design, modeling, and testing of a soft pneumatic glove with segmented pneuNets bending actuators. IEEE ASME Trans. Mechatron. 24, 990–1001 (2019).
Feng, M., Yang, D. & Gu, G. High-force fabric-based pneumatic actuators with asymmetric chambers and interference-reinforced structure for soft wearable assistive gloves. IEEE Robot. Autom. Lett. 6, 3105–3111 (2021).
Tang, Z. Q., Heung, H. L., Tong, K. Y. & Li, Z. Model-based online learning and adaptive control for a ‘human-wearable soft robot’ integrated system. Int. J. Rob. Res. 40, 256–276 (2021).
Li, H., Cheng, L., Li, Z. & Xue, W. Active disturbance rejection control for a fluid-driven hand rehabilitation device. IEEE ASME Trans. Mechatron. 26, 841–853 (2021).
Ge, L. et al. Design, modeling, and evaluation of fabric-based pneumatic actuators for soft wearable assistive gloves. Soft Robot. 7, 583–596 (2020).
Popov, D., Gaponov, I. & Ryu, J. H. Portable exoskeleton glove with soft structure for hand assistance in activities of daily living. IEEE ASME Trans. Mechatron. 22, 865–875 (2017).
Chen, X. et al. A wearable hand rehabilitation system with soft gloves. IEEE Trans. Industr. Inform. 17, 943–952 (2021).
Xiloyannis, M., Cappello, L., Khanh, D. B., Yen, S. C. & Masia, L. Modelling and design of a synergy-based actuator for a tendon-driven soft robotic glove. In 6th IEEE International Conference on Biomedical Robotics and Biomechatronics 1213–1219 (IEEE, 2016).
Nycz, C. J. et al. Design and characterization of a lightweight and fully portable remote actuation system for use with a hand exoskeleton. IEEE Robot. Autom. Lett. 1, 976–983 (2016).
Kang, B. B., Choi, H., Lee, H. & Cho, K. J. Exo-Glove Poly II: a polymer-based soft wearable robot for the hand with a tendon-driven actuation system. Soft Robot. 6, 214–227 (2019).
Dragusanu, M., Iqbal, M. Z., Baldi, T. L., Prattichizzo, D. & Malvezzi, M. Design, development, and control of a hand/wrist exoskeleton for rehabilitation and training. IEEE Trans. Robot. 38, 1472–1488 (2022).
Tran, P. et al. FLEXotendon Glove-III: voice-controlled soft robotic hand exoskeleton with novel fabrication method and admittance grasping control. IEEE ASME Trans. Mechatron. 27, 3920–3931 (2022).
Chen, W. et al. Soft exoskeleton with fully actuated thumb movements for grasping assistance. IEEE Trans. Robot. 38, 2194–2207 (2022).
Huang, X. et al. Chasing biomimetic locomotion speeds: creating untethered soft robots with shape memory alloy actuators. Sci. Robot. 3, eaau7557 (2018).
Yang, X., Chang, L. & Perez-Arancibia, N. O. An 88-milligram insect-scale autonomous crawling robot driven by a catalytic artificial muscle. Sci. Robot. 5, eaba0015 (2020).
Rodrigue, H., Wang, W., Han, M. W., Kim, T. J. Y. & Ahn, S. H. An overview of shape memory alloy-coupled actuators and robots. Soft Robot. 4, 3–15 (2017).
Jeong, J. et al. Wrist assisting soft wearable robot with stretchable coolant vessel integrated SMA muscle. IEEE ASME Trans. Mechatron. 27, 1046–1058 (2022).
Wang, W., Yu, C. Y., Abrego Serrano, P. A. & Ahn, S. H. Shape memory alloy-based soft finger with changeable bending length using targeted variable stiffness. Soft Robot. 7, 283–291 (2020).
Nguyen, X.-T., Calderon, A. A., Rigo, A., Ge, J. Z. & Perez-Arancibia, N. O. SMALLBug: a 30-mg crawling robot driven by a high-frequency flexible SMA microactuator. IEEE Robot. Autom. Lett. 5, 6796–6803 (2020).
Park, S. J., Kim, U. & Park, C. H. A novel fabric muscle based on shape memory alloy springs. Soft Robot. 7, 321–331 (2020).
Yang, H., Xu, M., Li, W. & Zhang, S. Design and implementation of a soft robotic arm driven by SMA coils. IEEE Trans. Ind. Electron. 66, 6108–6116 (2019).
Jin, H. et al. Modeling and motion control of a soft SMA planar actuator. IEEE ASME Trans. Mechatron. 27, 916–927 (2022).
Hadi, A., Alipour, K., Kazeminasab, S. & Elahinia, M. ASR glove: a wearable glove for hand assistance and rehabilitation using shape memory alloys. J. Intell. Mater. Syst. Struct. 29, 1575–1585 (2018).
Copaci, D., Arias, J., Gomez-Tome, M., Moreno, L. & Blanco, D. sEMG-based gesture classifier for a rehabilitation glove. Front. Neurorobot. 16, 750482 (2022).
Tran, P., Jeong, S., Herrin, K. R. & Desai, J. P. Hand exoskeleton systems, clinical rehabilitation practices, and future prospects. IEEE Trans. Med. Robot. Bionics 3, 606–622 (2021).
Zhang, D. R. et al. Real-time performance of hand motion recognition using kinematic signals for impaired hand function training. In 6th International IEEE EMBS Conference on Neural Engineering 339–342 (IEEE, 2013).
Liu, X. et al. Design of virtual guiding tasks with haptic feedback for assessing the wrist motor function of patients with upper motor neuron lesions. IEEE Trans. Neural Syst. Rehabil. Eng. 27, 984–994 (2019).
Dana, A., Vollach, S. & Shilo, D. Use the force: review of high-rate actuation of shape memory alloys. Actuators 10, 7 (2021).
Lagoudas, D. C. Shape Memory Alloys: Modeling and Engineering Applications (ed Lagoudas, D.) Ch. 1 (Springer, 2008).
Neumann, D. Kinesiology of the Musculoskeletal System: Foundation for Rehabilitation (ed Neumann, D.) Ch. 8 (Elsevier Mosby, 2016).
Kyberd, P. J. & Pons, J. L. A comparison of the Oxford and Manus intelligent hand prostheses. In 20th IEEE International Conference on Robotics and Automation 3231–3236 (IEEE, 2003).
Iberall, T. Human prehension and dexterous robot hands. Int. J. Rob. Res. 16, 285–299 (1997).
Cutkosky, M. R. & Wright, P. K. Modelling manufacturing grips and correlations with the design of robotic hands. In 1986 IEEE International Conference on Robotics and Automation 1533–1539 (IEEE, 1986).
Ciancio, A. L., Zollo, L., Baldassarre, G., Caligiore, D. & Guglielmelli, E. The role of thumb opposition in cyclic manipulation: a study with two different robotic hands. In 4th IEEE RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics 1092–1097 (IEEE, 2012).
Li, S. Spasticity, motor recovery, and neural plasticity after stroke. Front. Neurol. 8, 120 (2017).
Sui, M et al. A soft-packaged and portable rehabilitation glove capable of closed-loop fine motor skills. Zenodo https://doi.org/10.5281/zenodo.8172352 (2023).
Acknowledgements
This work is supported by National Natural Science Foundation of China (numbers 51975550, U21A20119, 12272369 and 51705495), National Key Research and Development Program of China (number 2022YFC2408100), Provincial Key Research and Development Program of Anhui Province (number 202104h04020004), Natural Science Foundation of Anhui Province of China under Grant 2008085UD02, and Fundamental Research Funds for the Central Universities (WK5290000002).
Author information
Authors and Affiliations
Contributions
Conceptualization: M.S., H.J., L.W. and S.Z. Methodology: M.S., Y.O., H.J., Z.C. and C.W. Investigation: M.S., Y.O., H.J., Z.C., C.W. and J.L. Visualization: M.S., Y.O., H.J., J.L., L.W. and S.Z. Funding acquisition: H.J., L.W. and S.Z. Project administration: H.J., L.W. and S.Z. Supervision: H.J., L.W. and S.Z. Writing—original draft: M.S., H.J. and L.W. Writing—review and editing: M.S., H.J., M.X., W.L., L.W. and S.Z.
Corresponding authors
Ethics declarations
Competing interests
M.S., Y.O., H.J. and S.Z. are inventors of an invention disclosure of the patent filed by University of Science and Technology of China (ZL202011284541.3, granted on 13 May 2022) related to this work. The other authors declare no competing interests.
Peer review
Peer review information
Nature Machine Intelligence thanks Xiaonan Huang for their contribution to the peer review of this work. Primary Handling Editor: Trenton Jerde, in collaboration with the Nature Machine Intelligence editorial team.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary information
Supplementary Information
Supplementary Text, Tables 1–3, Figs. 1–17 and legends for Supplementary Videos 1–10.
Supplementary Video 1
Overview of the soft-packaged and portable rehabilitation glove.
Supplementary Video 2
Human–machine interface.
Supplementary Video 3
Test of the maximum contact force of the fingertip.
Supplementary Video 4
Comparison of the noise level between various actuations.
Supplementary Video 5
Design of bending sensors.
Supplementary Video 6
Single-mode FMS rehabilitation on an individual with normal hands.
Supplementary Video 7
Switch-mode FMS rehabilitation on an individual with normal hands.
Supplementary Video 8
Single-mode FMS rehabilitation on a poststroke individual with an impaired right hand.
Supplementary Video 9
Switch-mode of FMS rehabilitation on a poststroke individual with an impaired right hand.
Supplementary Video 10
Assisted daily tasks on a poststroke individual.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Sui, M., Ouyang, Y., Jin, H. et al. A soft-packaged and portable rehabilitation glove capable of closed-loop fine motor skills. Nat Mach Intell 5, 1149–1160 (2023). https://doi.org/10.1038/s42256-023-00728-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/s42256-023-00728-z