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Reproduction

Slowing reproductive ageing by preserving BCAT-1

Nature Metabolism volume 6, pages 610–612 (2024)Cite this article

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In this issue of Nature Metabolism, it is shown that the abundance of Caenorhabditis elegans branched-chain aminotransferase-1 (BCAT-1) — which catalyses the first step of branched-chain amino acid (BCAA) catabolism — declines sharply in aged wild-type nematodes but not in slowly ageing mutants, and that stimulating BCAA catabolism extends reproductive longevity.

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Fig. 1: Proposed mechanism through which BCAT-1 may delay reproductive ageing.

References

  1. Richardson, N. E. et al. Nat. Aging 1, 73–86 (2021).

    Article  PubMed Central  PubMed  Google Scholar 

  2. Yu, D. et al. Cell Metab. 33, 905–922.e6 (2021).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. D’Antona, G. et al. Cell Metab. 12, 362–372 (2010).

    Article  PubMed  Google Scholar 

  4. Solon-Biet, S. M. et al. Nat. Metab. 1, 532–545 (2019).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  5. Lesnik, C. et al. Nat. Metab. https://doi.org/10.1038/s42255-024-00996-y (2024).

    Article  PubMed  Google Scholar 

  6. Mansfeld, J. et al. Nat. Commun. 6, 10043 (2015).

    Article  CAS  PubMed  Google Scholar 

  7. Cota, V., Sohrabi, S., Kaletsky, R. & Murphy, C. T. PLoS Genet. 18, e1010400 (2022).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Depuydt, G. et al. Mol. Cell. Proteom. 12, 3624–3639 (2013).

    Article  CAS  Google Scholar 

  9. Lee, Y. T. et al. Dev. Cell 58, 2718–2731.e7 (2023).

    Article  CAS  PubMed  Google Scholar 

  10. Luo, S., Kleemann, G. A., Ashraf, J. M., Shaw, W. M. & Murphy, C. T. Cell 143, 299–312 (2010).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Weir, H. J. et al. Cell Metab. 26, 884–896.e5 (2017).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Chaudhari, S. N. & Kipreos, E. T. Nat. Commun. 8, 182 (2017).

    Article  PubMed Central  PubMed  Google Scholar 

  13. Cretin, E. et al. EMBO Mol. Med. 13, e13579 (2021).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  14. Shen, E. Z. et al. Nature 508, 128–132 (2014).

    Article  CAS  PubMed  Google Scholar 

  15. Wang, M. C., Oakley, H. D., Carr, C. E., Sowa, J. N. & Ruvkun, G. PLoS Genet. 10, e1004752 (2014).

    Article  PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA

    Leah E. Jamerson & Patrick C. Bradshaw

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  1. Leah E. Jamerson
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  2. Patrick C. Bradshaw
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Correspondence to Patrick C. Bradshaw.

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The authors declare no competing interests.

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Jamerson, L.E., Bradshaw, P.C. Slowing reproductive ageing by preserving BCAT-1. Nat Metab 6, 610–612 (2024). https://doi.org/10.1038/s42255-024-01009-8

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