Individuals with osteoporosis have increased risk of Alzheimer’s disease or cognitive impairment during ageing. We elucidated a partial explanation for bone dysmetabolism’s association with such cognitive decline, by demonstrating how elevated sclerostin secretion from osteocytes in bone impaired cognitive function in aged mice and in an Alzheimer’s disease mouse model.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Chang, K. H. Increased risk of dementia in patients with osteoporosis: a population-based retrospective cohort analysis. Age (Dordr) 36, 967–975 (2014). This paper reports that osteoporosis patients exhibited 1.46-fold and 1.39-fold high risk of dementia and Alzheimer’s disease, respectively.
Han, Y., You, X., Xing, W., Zhang, Z. & Zou, W. Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts. Bone Res. 6, 16 (2018). A review that presents how bone cells, includingosteoclasts, osteoblasts and osteocytes, can act as endocrine organs to regulate the homeostasis of other organs.
Schaffler, M. B. Osteocyte signaling in bone. Curr. Osteoporos. Rep. 10, 118–125 (2012). This paper reports that osteocytes residing within the bone matrix make up between 90% to 95% of cellular components in mature bone tissue.
Dallas, S. L., Prideaux, M. & Bonewald, L. F. The osteocyte: an endocrine cell … and more. Endocrinol. Rev. 34, 658–690 (2013). A review that presents how osteocytes secret sclerostin to inhibit osteoblastogenesis by dysregulating the Wnt–β-catenin pathway.
Yuan, J. et al. Elevated plasma sclerostin is associated with high brain amyloid-beta load in cognitively normal older adults. npj Aging 9, 17 (2023). This paper reports that high plasma sclerostin is positively associated with high brain Aβ loading in older adults.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Shi, T. et al. Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer’s disease progression. Nat. Metab. https://doi.org/10.1038/s42255-024-00989-x (2024).
Rights and permissions
About this article
Cite this article
Sclerostin secreted from bone mediates cognitive decline in the brains of aged and Alzheimer’s disease mice. Nat Metab 6, 394–395 (2024). https://doi.org/10.1038/s42255-024-00990-4
Published:
Issue Date:
DOI: https://doi.org/10.1038/s42255-024-00990-4
