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Biochemistry

Optimizing metabolism is a complex issue

Electron transfer flavoprotein dehydrogenase (ETFDH), respiratory chain complex III and the coenzyme Q10 synthesis regulator COQ2 interact as a protein complex that is disrupted in ETFDH deficiency, with potential implications for disease therapy.

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Fig. 1: Mitochondrial energy metabolism and ETFDH.

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Correspondence to Jerry Vockley.

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Vockley, J. Optimizing metabolism is a complex issue. Nat Metab 6, 196–197 (2024). https://doi.org/10.1038/s42255-023-00965-x

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