Hypothalamic neural pathways control appetite and food intake, and thereby influence body weight and metabolism. De Solis et al. apply chemogenetics to simultaneously manipulate two subpopulations of hypothalamic neurons. Using this approach, the authors identify a pathway that regulates feeding behaviour.
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References
Rui, L. Rev. Endocr. Metab. Disord. 14, 387–407 (2013).
Brüning, J. C. & Fenselau, H. Science 381, eabl7398 (2023).
De Solis, A. J. et al. Nat. Metab. https://doi.org/10.1038/s42255-024-00987-z (2024).
Li, M. M. et al. Neuron 102, 653–667.e6 (2019).
Balthasar, N. et al. Cell 123, 493–505 (2005).
Li, C. et al. Cell Metab. 29, 681–694.e5 (2019).
Aklan, I. et al. Cell Metab. 31, 313–326.e5 (2020).
Acknowledgements
L.R. was supported by R01 DK114220 and R01 DK130111.
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Rui, L. Simultaneous targeting of POMC and AgRP neurons. Nat Metab 6, 382–383 (2024). https://doi.org/10.1038/s42255-023-00951-3
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DOI: https://doi.org/10.1038/s42255-023-00951-3
