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Subcellular quantitative imaging of metabolites at the organelle level

Nature Metabolism volume 5, pages 1446–1448 (2023)Cite this article

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Subcellular quantitative analysis has been a long-standing goal of mass spectrometry imaging, but was originally thought to be unattainable. However, recent advances have made organelle-level absolute quantification through mass spectrometry imaging a reality, thanks to the development of nano secondary ion mass spectrometry.

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Fig. 1: Organelle-level analysis at the sub-50 nm level, allowing MSI of cellular organelles, is now routinely possible.

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Authors and Affiliations

  1. Department of Chemistry, Scripps Research Institute, La Jolla, CA, USA

    Gary Siuzdak

  2. Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA, USA

    Gary Siuzdak

  3. Center for Metabolomics, Scripps Research Institute, La Jolla, CA, USA

    Gary Siuzdak

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  1. Gary Siuzdak
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Correspondence to Gary Siuzdak.

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Nature Metabolism thanks the anonymous reviewers for their contribution to the peer review of this work.

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Siuzdak, G. Subcellular quantitative imaging of metabolites at the organelle level. Nat Metab 5, 1446–1448 (2023). https://doi.org/10.1038/s42255-023-00882-z

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