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Cancer metabolism

Multimodal metabolomics pinpoint new metabolic vulnerability in colorectal cancer

Nature Metabolism volume 5, pages 1255–1257 (2023)Cite this article

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An Author Correction to this article was published on 11 October 2023

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By combining multimodal metabolomics technologies to investigate colorectal tissues and tumours in situ, Vande Voorde et al. found tumour genotype-specific metabolic profiles and revealed the methionine-cycle enzyme AHCY to be a potential therapeutic target in colorectal cancer.

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Fig. 1: Integrative multimodal metabolomics offer ways of classifying cancer types and uncover therapeutic vulnerabilities in cancer.

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Acknowledgements

W.L.T. is supported by the National Medical Research Council, Singapore (OFIRG21nov-0068, OFIRG19nov-0106, CTGIIT18may0012, NMRC/OFLCG/002-2018, MOH-OFLCG21jun-0001), National Research Foundation, Singapore (NRF-NRFI08-2022, NRF-CRP22-2019-0003, NRF-CRP23-2019-0004), Agency for Science, Technology and Research, Singapore, and the Singapore Ministry of Education under its Research Centres of Excellence initiative. M.Y.L. is supported by the A*STAR Career Development Fund: C210812014.

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Authors and Affiliations

  1. Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore

    May Yin Lee & Wai Leong Tam

  2. Cancer Science Institute of Singapore, National University of Singapore, Singapore, Republic of Singapore

    Wai Leong Tam

  3. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore

    Wai Leong Tam

  4. NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore

    Wai Leong Tam

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  1. May Yin Lee
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Correspondence to May Yin Lee or Wai Leong Tam.

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Lee, M.Y., Tam, W.L. Multimodal metabolomics pinpoint new metabolic vulnerability in colorectal cancer. Nat Metab 5, 1255–1257 (2023). https://doi.org/10.1038/s42255-023-00852-5

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