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Weight versus weight-independent effects of Roux-en-Y gastric bypass on type 2 diabetes

Nature Metabolism volume 5, pages 912–914 (2023)Cite this article

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Many people with obesity and type 2 diabetes achieve remission of their diabetes after Roux-en-Y gastric bypass surgery, but the mechanisms of remission remain disputed. We provide our perspective on competing datasets that point towards this effect being due either entirely to the loss of weight or to weight loss-independent effects.

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Acknowledgements

The writing of this article was supported by a number of awards from the NIH including P30 DK056341, P30 DK092950, P30DK20579, UL1 TR002345 (all to S.K.) and P01DK117821 P30DK089503, R01DK133140 (all to R.J.S.).

Author information

Authors and Affiliations

  1. Center for Human Nutrition, Washington University, St. Louis, Missouri, USA

    Samuel Klein

  2. Sansum Diabetes Research Institute, Santa Barbara, CA, USA

    Samuel Klein

  3. Department of Surgery, University of Michigan, Ann Arbor, MI, USA

    Randy J. Seeley

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  1. Samuel Klein
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Corresponding author

Correspondence to Randy J. Seeley.

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Competing interests

S.K. serves on scientific advisory boards for Altimmune and Merck and as a consultant for B2M Medical. R.J.S. has received research support from Novo Nordisk, Fractyl, Astra Zeneca and Eli Lilly. R.J.S. has served as a paid consultant for Novo Nordisk, Eli Lilly, Scohia, CinRx, Fractyl, Structure Therapeutics and Congruence Therapeutics. R.J.S. has equity in Calibrate and Rewind.

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Nature Metabolism thanks Caroline Apovian for their contribution to the peer review of this work.

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Klein, S., Seeley, R.J. Weight versus weight-independent effects of Roux-en-Y gastric bypass on type 2 diabetes. Nat Metab 5, 912–914 (2023). https://doi.org/10.1038/s42255-023-00823-w

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