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Neuroimaging

Obesity impairs brain responses to nutrients

Post-ingestive signals of nutrient availability can drive food reward and neural responses independently of orosensory signals. van Galen et al. demonstrate that brain responses to these post-ingestive signals are impaired in people with obesity

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Fig. 1: Macronutrient sensing is altered in people with obesity and not rescued by weight loss.

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Correspondence to Alexandra G. DiFeliceantonio.

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Baugh, M.E., DiFeliceantonio, A.G. Obesity impairs brain responses to nutrients. Nat Metab 5, 920–921 (2023). https://doi.org/10.1038/s42255-023-00822-x

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