PCYT2 is an enzyme involved in lipid biosynthesis, and its genetic deficiency in zebrafish, mice and humans causes progressive muscle weakness. Importantly, PCYT2 activity declines in ageing muscles of mice and humans, and PCYT2 gene therapy in aged mice improves muscle strength, suggesting new therapeutic avenues to explore for maintaining muscle health in ageing.
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This is a summary of: Cikes, D. et al. PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing. Nat. Metab. https://doi.org/10.1038/s42255-023-00766-2 (2023).
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A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing. Nat Metab 5, 368–369 (2023). https://doi.org/10.1038/s42255-023-00767-1
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DOI: https://doi.org/10.1038/s42255-023-00767-1
