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NAD+ metabolism

NAD+ and mtRNA sensing drive human kidney diseases

Nature Metabolism volume 5, pages 357–359 (2023)Cite this article

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Defective nicotinamide adenine dinucleotide (NAD+) metabolism is involved in various diseases. A study in Nature Metabolism identifies the cytosolic mitochondrial-RNA sensing system as a mediator that links NAD+ deficiency to kidney disease in humans and mice.

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Fig. 1: An NAD+-dependent mtRNA sensing mechanism for kidney disease.

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Authors and Affiliations

  1. Department of Endocrinology, Metabolism and Nephrology, Keio University School of Medicine, Tokyo, Japan

    Hiroshi Itoh & Jun Yoshino

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  1. Hiroshi Itoh
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  2. Jun Yoshino
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Correspondence to Hiroshi Itoh.

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The authors declare no competing interests.

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Itoh, H., Yoshino, J. NAD+ and mtRNA sensing drive human kidney diseases. Nat Metab 5, 357–359 (2023). https://doi.org/10.1038/s42255-023-00762-6

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