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Macrophage metabolism

Glycolysis modulates efferocytosis in a noncanonical manner

Nature Metabolism volume 5, pages 360–361 (2023)Cite this article

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The rate of glycolysis increases markedly during the phagocytosis of apoptotic cells and upon macrophage activation by inflammatory stimuli. However, the motive for burning glucose differs in both conditions.

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Fig. 1: Glycolysis support of efferocytosis differs from its role in the inflammatory activation of macrophages.

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Authors and Affiliations

  1. Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology–Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil

    Monara Kaélle Sérvulo Cruz Angelim & Pedro M. Moraes-Vieira

  2. Obesity and Comorbidities Research Center (OCRC), Experimental Medicine Research Cluster (EMRC), University of Campinas (UNICAMP), Campinas, Brazil

    Pedro M. Moraes-Vieira

Authors
  1. Monara Kaélle Sérvulo Cruz Angelim
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  2. Pedro M. Moraes-Vieira
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Correspondence to Pedro M. Moraes-Vieira.

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The authors declare no competing interests.

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Angelim, M.K.S.C., Moraes-Vieira, P.M. Glycolysis modulates efferocytosis in a noncanonical manner. Nat Metab 5, 360–361 (2023). https://doi.org/10.1038/s42255-023-00746-6

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