Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cell cycle

The cell cycle loops UTP around CAD

Nature Metabolism volume 5, pages 199–200 (2023)Cite this article

Subjects

Cell division is a highly regulated process and requires a concurrent supply of energy and nutrients. Shin et al. provide critical insights into the allosteric mechanisms by which UTP regulates CAD activity and pyrimidine synthesis during the cell cycle.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Allosteric control of CAD activity by UTP levels during the cell cycle.

References

  1. Fridman, A. et al. Biochem. J. 454, 91–99 (2013).

    Article  CAS  PubMed  Google Scholar 

  2. Lane, A. N. & Fan, T. W. Nucleic Acids Res. 43, 2466–2485 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Li, G., Li, D., Wang, T. & He, S. Int. J. Mol. Sci. 22, 10253 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Shin, J. et al. Nat. Metab. https://doi.org/10.1038/s42255-023-00735-9 (2023).

    Article  PubMed  Google Scholar 

  5. Sigoillot, F. D., Berkowski, J. A., Sigoillot, S. M., Kotsis, D. H. & Guy, H. I. J. Biol. Chem. 278, 3403–3409 (2003).

    Article  CAS  PubMed  Google Scholar 

  6. Liu, X., Guy, H. I. & Evans, D. R. J. Biol. Chem. 269, 27747–27755 (1994).

    Article  CAS  PubMed  Google Scholar 

  7. Graves, L. M. et al. Nature 403, 328–332 (2000).

    Article  CAS  PubMed  Google Scholar 

  8. Robitaille, A. M. et al. Science 339, 1320–1323 (2013).

    Article  CAS  PubMed  Google Scholar 

  9. Sigoillot, F. D. et al. Front. Biosci. 12, 3892–3898 (2007).

    Article  CAS  PubMed  Google Scholar 

  10. Moreno-Morcillo, M. et al. Structure 25, 912–923.e5 (2017).

    Article  CAS  PubMed  Google Scholar 

  11. Ben-Sahra, I., Howell, J. J., Asara, J. M. & Manning, B. D. Science 339, 1323–1328 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Villa, E., Ali, E. S., Sahu, U. & Ben-Sahra, I. Cancers 11, 688 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. de Cima, S. et al. Sci. Rep. 5, 16950 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Umakant Sahu & Issam Ben-Sahra

  2. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA

    Umakant Sahu & Issam Ben-Sahra

Authors
  1. Umakant Sahu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Issam Ben-Sahra
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Issam Ben-Sahra.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sahu, U., Ben-Sahra, I. The cell cycle loops UTP around CAD. Nat Metab 5, 199–200 (2023). https://doi.org/10.1038/s42255-023-00737-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s42255-023-00737-7

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research