Dai and colleagues show that activation of AMPK by glucose starvation leads to phosphorylation of GATOR2 and affects nutrient-dependent activation of mTORC1.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Liu, G. Y. & Sabatini, D. M. Nat. Rev. Mol. Cell Biol. https://doi.org/10.1038/s41580-019-0199-y (2020).
Valvezan, A. J. & Manning, B. D. Nat. Metab. 1, 321–333 (2019).
Saxton, R. A. & Sabatini, D. M. Cell https://doi.org/10.1016/j.cell.2017.02.004 (2017).
Lawrence, R. E. & Zoncu, R. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0244-7 (2019).
Orozco, J. M. et al. Nat. Metab. 2, 893–901 (2020).
Efeyan, A. et al. Nature 493, 679–683 (2013).
Inoki, K., Zhu, T. & Guan, K. L. Cell 115, 577–590 (2003).
Gwinn, D. M. et al. Mol. Cell 30, 214–226 (2008).
Dai, X et al. Nat. Metab. https://doi.org/10.1038/s42255-022-00732-4 (2023).
Efeyan, A. et al. Dev. Cell 29, 321–329 (2014).
Kim, Y. C. et al. Nat. Commun. https://doi.org/10.1038/ncomms5241 (2014).
Peng, M., Yin, N. & Li, M. O. Cell 159, 122–133 (2014).
Chantranupong, L. et al. Cell Rep. 9, 1–8 (2014).
Acknowledgements
A.E. laboratory acknowledges funding by a RETOS Projects Program of the Spanish Ministry of Science, Innovation and Universities, the Spanish State Research Agency (AEI/10.13039 /501100011033) co-funded by the European Regional Development Fund (PID2019-104012RB-I00), a FERO Grant for Research in Oncology and the LaCaixa Banking Foundation (LCF/PR/HR21/0046). A.E. is an EMBO Young Investigator.
Author information
Authors and Affiliations
Contributions
N.D.-S. and A.E. wrote and edited the text and figure.
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Deleyto-Seldas, N., Efeyan, A. AMPK knocks at the gate of GATOR. Nat Metab 5, 197–198 (2023). https://doi.org/10.1038/s42255-022-00729-z
Published:
Issue Date:
DOI: https://doi.org/10.1038/s42255-022-00729-z
