Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Lipid homeostasis

Asters: rising stars in the cholesterol universe

Intracellular trafficking of cholesterol is essential for its uptake, storage and export. In this issue of Nature Metabolism, Xiao et al. provide powerful evidence for the importance of hepatic GRAMD1/Aster transporters in maintaining systemic cholesterol homeostasis.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Role of Aster proteins in mouse hepatic cholesterol transport.


  1. Ikonen, E. & Zhou, X. Dev. Cell 56, 1430–1436 (2021).

    Article  CAS  Google Scholar 

  2. Das, A., Brown, M. S., Anderson, D. D., Goldstein, J. L. & Radhakrishnan, A. eLife 3, e02882 (2014).

    Article  Google Scholar 

  3. Brown, M. S., Radhakrishnan, A. & Goldstein, J. L. Annu. Rev. Biochem. 87, 783–807 (2018).

    Article  CAS  Google Scholar 

  4. Gatta, A. T. et al. eLife 4, e07253 (2015).

    Article  Google Scholar 

  5. Ercan, B., Naito, T., Koh, D. H. Z., Dharmawan, D. & Saheki, Y. EMBO J. 40, e106524 (2021).

    Article  CAS  Google Scholar 

  6. Besprozvannaya, M. et al. eLife 7, e31019 (2018).

    Article  Google Scholar 

  7. Sandhu, J. et al. Cell 175, 514–529.e20 (2018).

    Article  CAS  Google Scholar 

  8. Naito, T. et al. eLife 8, e51401 (2019).

    Article  CAS  Google Scholar 

  9. Trinh, M. N. et al. Proc. Natl Acad. Sci. USA 119, e2120411119 (2022).

    Article  Google Scholar 

  10. Xiao, X. et al. Nat. Metab. (2023).

    Article  Google Scholar 

  11. Gay, A., Rye, D. & Radhakrishnan, A. Biophys. J. 108, 1459–1469 (2015).

    Article  CAS  Google Scholar 

  12. Wang, H. et al. Mol. Cell 73, 458–473.e7 (2019).

    Article  CAS  Google Scholar 

  13. Zhao, K. & Ridgway, N. D. Cell Rep. 19, 1807–1818 (2017).

    Article  CAS  Google Scholar 

  14. Laraia, L. et al. Nat. Chem. Biol. 15, 710–720 (2019).

    Article  CAS  Google Scholar 

  15. Wang, X. et al. Cell Metab. 31, 969–986.e7 (2020).

    Article  Google Scholar 

Download references


The Brown Laboratory is supported by an Australian Research Council Discovery Project Grant DP170101178. H.W.C. is in receipt of a UNSW Science Writing Scholarship.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Andrew J. Brown.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Coates, H.W., Brown, A.J. Asters: rising stars in the cholesterol universe. Nat Metab 5, 16–18 (2023).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing