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A stochastic basis for metabolic phenotypes

It has long been recognized that some phenotypic variation in mammals cannot be explained by known genetic or environmental variables. Here, the authors show that the absence of Nnat expression is associated with polyphenism in mice with the same genotype. Broadly consistent effects are also found in humans.

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Fig. 1: A mouse model for understanding the origins of unexplained phenotypic variation.

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Correspondence to Michelle L. Holland or Vardhman K. Rakyan.

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Holland, M.L., Rakyan, V.K. A stochastic basis for metabolic phenotypes. Nat Metab 4, 1091–1092 (2022). https://doi.org/10.1038/s42255-022-00630-9

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