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Methanol-tolerant yeast for biofuel production

Methanol is a promising feedstock owing to its low price, abundance, energy richness and renewability. However, the toxicity of methanol limits methanol-based biomanufacturing. Rescuing methylotrophic yeast from cell death by restoring phospholipid metabolism enables high-level production of free fatty acids from methanol.

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Fig. 1: Methanol-based sustainable biomanufacturing enabled by tolerance and metabolic engineering.


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E.Y.L. and A.S. are supported by the C1 Gas Refinery Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT (2015M3D3A1A01064882).

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Correspondence to Eun Yeol Lee.

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Lee, E.Y., Sarwar, A. Methanol-tolerant yeast for biofuel production. Nat Metab 4, 800–801 (2022).

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