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LIPID METABOLISM

NAD+ regeneration drives cancer cell proliferation

Nature Metabolism volume 4, pages 647–648 (2022)Cite this article

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NAD+ is a key electron acceptor in proliferating cells, needed to increase biomass. Computational and experimental approaches demonstrate that NAD+ regeneration is critical for de novo lipid synthesis when exogenous sources are limited, underlying cancer cell dependence on lipids when mitochondrial respiration is reduced.

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Fig. 1: Essentiality of lipid biomass precursors for proliferation under the stress of reduced mitochondrial respiration and absence of exogenous lipids.

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Authors and Affiliations

  1. Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Xu Han & M. Celeste Simon

  2. Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA

    M. Celeste Simon

Authors
  1. Xu Han
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  2. M. Celeste Simon
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Correspondence to M. Celeste Simon.

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The authors declare no competing interests.

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Han, X., Simon, M.C. NAD+ regeneration drives cancer cell proliferation. Nat Metab 4, 647–648 (2022). https://doi.org/10.1038/s42255-022-00586-w

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