Itaconate is an immunomodulatory Krebs cycle-derived metabolite. Description of two isomers of itaconate, mesaconate and citraconate, which have overlapping and distinct properties when compared with itaconate in macrophages, expands the knowledge of this intriguing family of immunomodulatory metabolites.
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The authors were funded by the European Research Council (834370) and Science Foundation Ireland (210474).
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McGettrick, A.F., O’Neill, L.A.J. The itaconate family of immunomodulators grows. Nat Metab 4, 499–500 (2022). https://doi.org/10.1038/s42255-022-00578-w
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DOI: https://doi.org/10.1038/s42255-022-00578-w
