GDF15 is a hormone with the potential to regulate energy intake. GDF15 signals via the GFRAL/RET receptor complex, and besides the ligand activation of the receptor complex, our knowledge on control of receptor signalling is limited. Chow et al. show that MT1-MMP controls GDF15 actions by regulating levels of GFRAL.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Johnen, H. et al. Nat. Med. 13, 1333–1340 (2007).
Wang, D. et al. Nat. Rev. Endocrinol. 17, 592–607 (2021).
Lockhart, S. M., Saudek, V. & O’Rahilly, S. Endocr. Rev. 41, bnaa007 (2020).
Kleinert, M. et al. Mol. Metab. 9, 187–191 (2018).
Tong, S. et al. Lancet 363, 129–130 (2004).
Yang, L. et al. Nat. Med. 23, 1158–1166 (2017).
Frikke-Schmidt, H. et al. Mol. Metab. 21, 13–21 (2019).
Xiong, Y. et al. Sci. Transl. Med. 9, eaan8732 (2017).
Sabatini, P. V. et al. Proc. Natl Acad. Sci. USA 118, e2021357118 (2021).
Fejzo, M. S. et al. Geburtshilfe Frauenheilkd. 79, 382–388 (2019).
Borner, T. et al. Cell Metab. 31, 351–362.e5 (2020).
Mullican, S. E. et al. Nat. Med. 23, 1150–1157 (2017).
Chow, C. F. W. et al. Nat. Metab. https://doi.org/10.1038/s42255-022-00529-5 (2022).
Dostálová, I. et al. Eur. J. Endocrinol. 161, 397–404 (2009).
Bjørbaek, C., El-Haschimi, K., Frantz, J. D. & Flier, J. S. J. Biol. Chem. 274, 30059–30065 (1999).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
S.B.J. and M.T.C are employed at Novo Nordisk A/S, a pharmaceutical company that manufactures and vends medicine.
Rights and permissions
About this article
Cite this article
Jørgensen, S.B., Tang-Christensen, M. Central regulation of the anorexigenic receptor GFRAL. Nat Metab 4, 157–158 (2022). https://doi.org/10.1038/s42255-022-00535-7
Published:
Issue Date:
DOI: https://doi.org/10.1038/s42255-022-00535-7
