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Cellular and molecular brakes on adipogenesis

De novo adipocyte differentiation ensures healthy adipose tissue expansion and protects against deleterious ectopic lipid deposition in the setting of overnutrition. Dong and Sun et al. identify a molecular brake on adipogenesis that may contribute to the development of insulin resistance in obesity.

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Fig. 1: R-spondin 2 signaling is associated with unhealthy adipose tissue expansion.


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The authors are supported by National Institutes of Health NIDDK awards R01 DK104789, RC2 DK118620 and R01 DK119163 to R.K.G.

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Correspondence to Rana K. Gupta.

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The authors declare no competing interests.

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Cannavino, J., Gupta, R.K. Cellular and molecular brakes on adipogenesis. Nat Metab 4, 13–14 (2022).

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