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DEVELOPMENTAL BIOLOGY

Oocyte metabolites are heritable factors that drive metabolic reprogramming of the progeny

The maternal diet can impact offspring development, yet the mechanisms responsible for this remain largely unknown. New research shows that oocyte metabolites, specifically NAD+ and the methyl donor S-adenosylmethionine, can mediate the impact of maternal nutrient stress on the progeny through metabolic reprogramming in Drosophila.

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Fig. 1: Oocyte metabolites serve as the potential heritable factors that drive reprogramming of progeny metabolism.

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Correspondence to Qiang Wang.

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Zhu, S., Wang, Q. Oocyte metabolites are heritable factors that drive metabolic reprogramming of the progeny. Nat Metab 3, 1148–1149 (2021). https://doi.org/10.1038/s42255-021-00447-y

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