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NUTRITION

We are more than what we eat

When is a calorie not just a calorie? In the current issue of Nature Metabolism, Roy et al. use recombinant inbred strains of mice to investigate the role of genetic background in the response to dietary fat. Notably, both lifespan and weight gain have been found to be highly dependent on genotype, thus highlighting the need for a personalized approach to dietary interventions.

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Fig. 1: Genetic variation promotes a diverse response to high-fat-diet feeding.

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Acknowledgements

C.L.G. is supported by a postdoctoral fellowship from the Glenn Foundation for Medical Research. D.W.L. is supported in part by the National Institute on Aging (AG056771, AG062328 and AG061635) and the US Department of Veterans Affairs (I01-BX004031). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. This work does not represent the views of the Department of Veterans Affairs or the United States Government.

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Correspondence to Dudley W. Lamming.

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D.W.L. has received funding from, and is a scientific advisory board member of, Aeovian Pharmaceuticals, which seeks to develop novel, selective mTOR inhibitors for the treatment of various diseases. C.L.G. declares no conflicts of interest.

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Green, C.L., Lamming, D.W. We are more than what we eat. Nat Metab 3, 1144–1145 (2021). https://doi.org/10.1038/s42255-021-00434-3

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