Obesity is a growing public-health problem that has been linked to lifestyle changes affecting the diet, which in turn may lead to changes in the commensal microbiota. Hild et al. show that mice colonized with microbiota derived from wild-caught mice are protected against diet-induced obesity, specifically when this microbial colonization occurs early in life.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Sonnenburg, E. D. & Sonnenburg, J. L. Nat. Rev. Microbiol. 17, 383–390 (2019).
Bisanz, J. E., Upadhyay, V., Turnbaugh, J. A., Ly, K. & Turnbaugh, P. J. Cell Host Microbe 26, 265–272 e264 (2019).
Sonnenburg, E. D. et al. Nature 529, 212–215 (2016).
Hild, B. et al. Nat. Metab. https://doi.org/10.1038/s42255-021-00439-y (2021).
Seok, J. et al. Proc. Natl Acad. Sci. USA 110, 3507–3512 (2013).
Beura, L. K. et al. Nature 532, 512–516 (2016).
Rosshart, S. P. et al. Cell 171, 1015–1028.e1013 (2017).
Rosshart, S. P. et al. Science 365, eaaw4361 (2019).
Turnbaugh, P. J. et al. Nature 444, 1027–1031 (2006).
Cox, L. M. et al. Cell 158, 705–721 (2014).
Al Nabhani, Z. et al. Immunity 50, 1276–1288.e1275 (2019).
Acknowledgements
We thank R. Patry for discussion and review in preparation of the article.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
C.R.N. is the president and cofounder of ClostraBio, Inc. L.A.H. declares no competing interests.
Rights and permissions
About this article
Cite this article
Hesser, L.A., Nagler, C.R. A wild approach to obesity prevention. Nat Metab 3, 1038–1039 (2021). https://doi.org/10.1038/s42255-021-00426-3
Published:
Issue Date:
DOI: https://doi.org/10.1038/s42255-021-00426-3