AMPK is a crucial sensor of the cellular energetic state and is also activated during glucose starvation. A new study reports that AMP-activated protein kinase (AMPK) is activated by interaction with long-chain fatty acyl–CoA esters, which appear to be the long-sought endogenous AMPK ligands that bind the allosteric drug and metabolite (ADaM) site.
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Hardie, D.G. AMPK as a direct sensor of long-chain fatty acyl–CoA esters. Nat Metab 2, 799–800 (2020). https://doi.org/10.1038/s42255-020-0249-y
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DOI: https://doi.org/10.1038/s42255-020-0249-y
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