The mechanistic target of rapamycin complex 1 (mTORC1) network integrates nutrient and energy signals that regulate metabolism and cell growth. Orozco et al. now show that the glycolytic intermediate dihydroxyacetone phosphate (DHAP) relays glycolytic activity to mTORC1 signalling.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Efeyan, A., Comb, W. C. & Sabatini, D. M. Nature 517, 302–310 (2015).
Saxton, R. A. & Sabatini, D. M. Cell 169, 361–371 (2017).
Valvezan, A. J. & Manning, B. D. Nat. Metab. 1, 321–333 (2019).
Lawrence, R. E. & Zoncu, R. Nat. Cell Biol. 21, 133–142 (2019).
Hardie, D. G. Genes Dev. 25, 1895–1908 (2011).
Shaw, R. J. et al. Cancer Cell 6, 91–99 (2004).
Efeyan, A. et al. Dev. Cell 29, 321–329 (2014).
Zhang, C.-S. et al. Nature 548, 112–116 (2017).
Orozco, J. M. et al. Nat. Metab. https://doi.org/10.1038/s42255-020-0250-5 (2020).
Liberti, M. V. et al. Cell Metab. 26, 648–659.e8 (2017).
Shestov, A. A. et al. elife 3, e03342 (2014).
Quinn, W. J. III et al. J. Clin. Invest. 127, 4207–4215 (2017).
Kornberg, M. D. et al. Science 360, 449–453 (2018).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Hoxhaj, G., Locasale, J.W. & Ben-Sahra, I. A spoonful of DHAP keeps mTORC1 running on sugars. Nat Metab 2, 801–802 (2020). https://doi.org/10.1038/s42255-020-0246-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s42255-020-0246-1