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Conversion of a dietary fructose: new clues from the gut microbiome

Fructose, a monosaccharide derived from fruits, is primarily consumed in a form combined with glucose as sugar or as a component of high-fructose corn syrup added as a sweetener to processed foods and carbonated beverages. Increased consumption of fructose has emerged as a major contributor to non-alcoholic fatty liver disease, dyslipidaemia, insulin resistance and diabetes. Now Zhao et al. show that hepatic lipid synthesis is increased by fructose metabolism in both the liver and intestine.

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Fig. 1: A novel microbiota–hepatocyte–lipogenesis pathway is required for conversion of dietary fructose.


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Correspondence to Catherine Postic.

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Postic, C. Conversion of a dietary fructose: new clues from the gut microbiome. Nat Metab 2, 217–218 (2020).

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