A creatine futile cycle has been shown to contribute to energy expenditure in beige adipocytes in preclinical mouse models of obesity. In this issue of Nature Metabolism, Connell and colleagues show that creatine supplementation in healthy young female vegetarians unfortunately affects neither human brown adipocyte activity nor cold-induced energy expenditure.
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Modica, S., Wolfrum, C. Creatine supplementation and thermogenesis in humans—a futile exercise?. Nat Metab 3, 9–10 (2021). https://doi.org/10.1038/s42255-020-00337-9
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DOI: https://doi.org/10.1038/s42255-020-00337-9
