The heart is an organ with high energy demands and metabolic flexibility, thus allowing for various energy substrates for ATP production under different physiological conditions. Zhang et al., Fernandez-Caggiano et al. and McCommis et al. converge on the mitochondrial pyruvate transporter as a key metabolic hub for the maintenance of cardiac metabolism and a critical determinant of cardiac metabolic plasticity during heart failure.
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This work was supported by a grant from the Else-Kröner Fresenius Foundation (to P.C.S.).
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Schulze, P.C., Wu, J.M.F. Ketone bodies for the starving heart. Nat Metab 2, 1183–1185 (2020). https://doi.org/10.1038/s42255-020-00310-6
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DOI: https://doi.org/10.1038/s42255-020-00310-6