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CARDIAC METABOLISM

Ketone bodies for the starving heart

The heart is an organ with high energy demands and metabolic flexibility, thus allowing for various energy substrates for ATP production under different physiological conditions. Zhang et al., Fernandez-Caggiano et al. and McCommis et al. converge on the mitochondrial pyruvate transporter as a key metabolic hub for the maintenance of cardiac metabolism and a critical determinant of cardiac metabolic plasticity during heart failure.

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Fig. 1: Cardiac intermediary metabolism in normal and failing myocardium, and the role of the ketogenic diet in correcting substrate metabolism in heart failure.

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Acknowledgements

This work was supported by a grant from the Else-Kröner Fresenius Foundation (to P.C.S.).

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Schulze, P.C., Wu, J.M.F. Ketone bodies for the starving heart. Nat Metab 2, 1183–1185 (2020). https://doi.org/10.1038/s42255-020-00310-6

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