A new global measure of cell-to-cell transcriptional variability from single-cell RNA-sequencing data has been developed by Levy et al., on the basis of the transcriptional interrelations between genes. The new variable, termed global coordination level, decreases with age in different organisms and cell types and correlates with high mutational load in cells.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kirkwood, T. B. Cell 120, 437–447 (2005).
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. Cell 153, 1194–1217 (2013).
Chalancon, G. et al. Trends Genet. 28, 221–232 (2012).
Bahar, R. et al. Nature 441, 1011–1014 (2006).
Enge, M. et al. Cell 171, 321–330.e314 (2017).
Angelidis, I. et al. Nat. Commun. 10, 963 (2019).
Vijg, J. & Dong, X. Cell 182, 12–23 (2020).
Levy, O. et al. Nat. Metabol. https://doi.org/10.1038/s42255-020-00304-4 (2020).
Ono, T. & Cutler, R. G. Proc. Natl Acad. Sci. USA 75, 4431–4435 (1978).
Martin, G. M. Mech. Ageing Dev. 133, 107–111 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
J.V. is a cofounder of and stock holder in SingulOmics, Corp., USA.
Rights and permissions
About this article
Cite this article
Vijg, J. Loss of gene coordination as a stochastic cause of ageing. Nat Metab 2, 1188–1189 (2020). https://doi.org/10.1038/s42255-020-00295-2
Published:
Issue Date:
DOI: https://doi.org/10.1038/s42255-020-00295-2