The restoration of the progressive decline in nicotinamide adenine dinucleotide (NAD+) levels mitigates certain age-associated dysfunctions. A fundamental question is how the NAD+-consuming enzyme CD38 decreases NAD+ levels during ageing. Two new studies by Chini et al. and Covarrubias et al. in this issue of Nature Metabolism show that CD38 expression in macrophages induced by senescence-associated inflammation accounts for the age-related decline in NAD+ levels.
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References
Verdin, E. Science 350, 1208–1213 (2015).
Katsyuba, E., Romani, M., Hofer, D. & Auwerx, J. Nat Metab 2, 9–31 (2020).
Zhao, Y. J., Lam, C. M. & Lee, H. C. Sci. Signal. 5, ra67 (2012).
Shrimp, J. H. et al. J. Am. Chem. Soc. 136, 5656–5663 (2014).
Billington, R. A. et al. Mol. Med. 12, 324–327 (2006).
De Flora, A., Guida, L., Franco, L. & Zocchi, E. Int. J. Biochem. Cell Biol. 29, 1149–1166 (1997).
Camacho-Pereira, J. et al. Cell Metab. 23, 1127–1139 (2016).
Tarrago, M. G. et al. Cell Metab. 27, 1081–1095.e1010 (2018).
Chini, C. C. S. et al. Nat. Metab. https://doi.org/10.1038/s42255-020-00298-z (2020).
Covarrubias, A. J. et al. Nat. Metab. https://doi.org/10.1038/s42255-020-00305-3 (2020).
Amici, S. A. et al. Front Immunol. 9, 1593 (2018).
Coppé, J. P., Desprez, P. Y., Krtolica, A. & Campisi, J. Annu. Rev. Pathol. 5, 99–118 (2010).
van Deursen, J. M. Nature 509, 439–446 (2014).
Xu, M. et al. Nat. Med. 24, 1246–1256 (2018).
Nacarelli, T. et al. Nat. Cell Biol. 21, 397–407 (2019).
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Wu, S., Zhang, R. CD38-expressing macrophages drive age-related NAD+ decline. Nat Metab 2, 1186–1187 (2020). https://doi.org/10.1038/s42255-020-00292-5
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DOI: https://doi.org/10.1038/s42255-020-00292-5
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