Teaching an old dog new tricks: metformin induces body-weight loss via GDF15

GDF15 is an anorectic hormone that relays systemic stress to the brain. In the current issue of Nature Metabolism, Day et al. elegantly demonstrate that the frontline anti-diabetes drug, metformin, lowers body weight by increasing circulating levels of GDF15.

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Fig. 1: Body-weight loss in response to metformin treatment depends on GDF15 release.


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Correspondence to Timo D. Müller.

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Competing interests

T.D.M. receives research support from Novo Nordisk and Sanofi-Aventis. The funders had no role in the writing of the manuscript or in the decision to publish this manuscript. M.K. declares no conflicts of interest.

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Kleinert, M., Müller, T.D. Teaching an old dog new tricks: metformin induces body-weight loss via GDF15. Nat Metab 1, 1171–1172 (2019).

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