Nuclear DNA damage has detrimental effects on cellular homoeostasis and accelerates the ageing process. A new study causally links error-prone mitochondrial replication to increased nuclear DNA damage, thus suggesting that the hallmarks of ageing are associated with nuclear genome instability, a potential unifying denominator in the ageing process.
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Schumacher, B., Vijg, J. Age is in the nucleus. Nat Metab 1, 931–932 (2019). https://doi.org/10.1038/s42255-019-0125-9