Speed-dieting: dopamine agonists promote weight loss

Article metrics

Dopamine is an important neurotransmitter with essential roles in movement control and salience, and implications in addiction as well as weight loss, decreased food intake and a reduced motivational drive to eat. Folgueira et al. now demonstrate that dopamine causes weight loss and increases brown adipose tissue temperature via activation of the dopamine receptor D2R in hypothalamic GABA-expressing neurons in mice, and treatment with the dopamine agonist cabergoline causes weight loss in humans.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Schematic of the potential circuitry through which LHA/ZI D2R agonism might increase BAT temperature in an Orexin A/Orexin 1 receptor–dependent manner.


  1. 1.

    Folgueira, C. et al. Nat. Metab. https://doi.org/10.1038/s42255-019-0099-7 (2019).

  2. 2.

    Cerri, M. & Morrison, S. F. Neuroscience 135, 627–638 (2005).

  3. 3.

    Tupone, D., Madden, C. J., Cano, G. & Morrison, S. F. J. Neurosci. 31, 15944–15955 (2011).

  4. 4.

    Martins, L. et al. Cell Rep. 16, 2231–2242 (2016).

  5. 5.

    Zhang, X. & van den Pol, A. N. Science 356, 853–859 (2017).

  6. 6.

    Davis, C. et al. Int. J. Neuropsychopharmacol. 15, 181–187 (2012).

Download references

Author information

Correspondence to Michael A. Cowley.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark