Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter

Matters Arising to this article was published on 12 July 2019

The Original Article was published on 07 January 2019

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Ratajczak, J. et al. NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells. Nat. Commun. 7, 13103 (2016).

    CAS  Article  Google Scholar 

  2. 2.

    Grozio, A. et al. Slc12a8 is a nicotinamide mononucleotide transporter. Nat. Metab. 1, 47–57 (2019).

    Article  Google Scholar 

  3. 3.

    Yoshino, J., Mills, K. F., Yoon, M. J. & Imai, S.Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.Cell Metab. 14, 528–536 (2011).

    CAS  Article  Google Scholar 

  4. 4.

    Yoshino, J. & Imai, S. Accurate measurement of nicotinamide adenine dinucleotide (NAD+) with high-performance liquid chromatography. Methods Mol. Biol. 1077, 203–215 (2013).

    CAS  Article  Google Scholar 

  5. 5.

    Trammell, S. A. et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat. Commun. 7, 12948 (2016).

    CAS  Article  Google Scholar 

  6. 6.

    Trammell, S. A. & Brenner, C. Targeted, LCMS-based metabolomics for quantitative measurement of NAD+ metabolites. Comput. Struct. Biotechnol. J. 4, e201301012 (2013).

    Article  Google Scholar 

  7. 7.

    Zhao, Z. Y. et al. A cell-permeant mimetic of NMN activates SARM1 to produce cyclic ADP-ribose and induce non-apoptotic cell death. iScience 15, 452–466 (2019).

    CAS  Article  Google Scholar 

  8. 8.

    Nikiforov, A., Dölle, C., Niere, M. & Ziegler, M. Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation. J. Biol. Chem. 286, 21767–21778 (2011).

    CAS  Article  Google Scholar 

  9. 9.

    Grozio, A. et al. CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells. J. Biol. Chem. 288, 25938–25949 (2013).

    CAS  Article  Google Scholar 

  10. 10.

    Sociali, G. et al. Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model. Oncotarget 7, 2968–2984 (2016).

    Article  Google Scholar 

  11. 11.

    Fletcher, R. S. et al. Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells. Mol. Metab. 6, 819–832 (2017).

    CAS  Article  Google Scholar 

  12. 12.

    Vaur, P. et al. Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration. FASEB J. 31, 5440–5452 (2017).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Contributions

M.S.S. and C.B. analysed the data. C.B. wrote the manuscript.

Corresponding author

Correspondence to Charles Brenner.

Ethics declarations

Competing interests

C.B. owns stock in and is chief scientific adviser to ChromaDex, Inc. M.S. declares no competing interests.

Additional information

Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Schmidt, M.S., Brenner, C. Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter. Nat Metab 1, 660–661 (2019). https://doi.org/10.1038/s42255-019-0085-0

Download citation

Further reading

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing