Understanding the mechanisms by which tumour cells adapt or succumb to targeted therapies is crucial to improving cancer treatment. A study in this issue of Nature Metabolism demonstrates how microRNAs, metabolic pathways and pseudohypoxia play a major role in the drug tolerance to epidermal growth factor receptor (EGFR) inhibitors in lung adenocarcinoma.
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Calin, G.A., Pardini, B. Mir-roring hypoxia in EGFR-TKI tolerance. Nat Metab 1, 418–419 (2019). https://doi.org/10.1038/s42255-019-0057-4
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DOI: https://doi.org/10.1038/s42255-019-0057-4
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