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CANCER METABOLISM

Minding the Ls and Qs

Nature Metabolism volume 1, pages 308–309 (2019)Cite this article

As one of the most highly consumed amino acids in cultured cancer cells, glutamine is an attractive target for anti-cancer therapy, and glutaminase inhibitors are currently in clinical trials. In this issue, Ni et al. show that blocking this pathway by targeting the glutamine importer ASCT2 (SLC1A5) decreases tumorigenesis in mouse leukaemia models while largely sparing normal haematopoiesis.

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Fig. 1: Contributions of glutamine to metabolism and mTORC1 signalling.

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Authors and Affiliations

  1. Department of Pathology, New York University School of Medicine, New York, NY, USA

    Richard Possemato

  2. Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY, USA

    Richard Possemato

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  1. Richard Possemato
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Correspondence to Richard Possemato.

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Possemato, R. Minding the Ls and Qs. Nat Metab 1, 308–309 (2019). https://doi.org/10.1038/s42255-019-0046-7

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