Go with the flow—hidden vascular passages in bone

The circulatory system in long bones is incompletely understood. A new study published in Nature Metabolism unveils the presence of dense vascular networks in long bones that facilitate the egress of bone marrow cells and potentially the exchange of nutrients between the bone marrow and the systemic circulation.

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Fig. 1: Formation and function of trans-cortical vein canals within compact bone.


  1. 1.

    Grüneboom, A. et al. Nat. Metab. (2019).

  2. 2.

    Teitelbaum, S. L. Bone resorption by osteoclasts. Science 289, 1504–1508 (2000).

    CAS  Article  Google Scholar 

  3. 3.

    Stains, J. P. & Civitelli, R. Biochim. Biophys. Acta 1719, 69–81 (2005).

    CAS  Article  Google Scholar 

  4. 4.

    Herisson, F. et al. Nat. Neurosci. 21, 1209–1217 (2018).

    CAS  Article  Google Scholar 

  5. 5.

    Marinova-Mutafchieva, L., Williams, R. O., Funa, K., Maini, R. N. & Zvaifler, N. J. Arthritis Rheum. 46, 507–513 (2002).

    CAS  Article  Google Scholar 

  6. 6.

    Werner, D. et al. Arthritis Rheumatol. 69, 1580–1587 (2017).

    Article  Google Scholar 

  7. 7.

    Ortega-Gómez, A., Perretti, M. & Soehnlein, O. EMBO Mol. Med. 5, 661–674 (2013).

    Article  Google Scholar 

  8. 8.

    Ramasamy, S. K. et al. Nat. Commun. 7, 13601 (2016).

    Article  Google Scholar 

  9. 9.

    Nakashima, T. et al. Nat. Med. 17, 1231–1234 (2011).

    CAS  Article  Google Scholar 

  10. 10.

    Fullerton, J. N. & Gilroy, D. W. Nat. Rev. Drug Discov. 15, 551–567 (2016).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Christopher Ritchlin.

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Competing interests

I.A. has received consultancy fees/grants from Pfizer, Schering-Plough/Merck, Tanabe Research Labs, and Novartis. C.R. declares no competing interests.

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Ritchlin, C., Adamopoulos, I.E. Go with the flow—hidden vascular passages in bone. Nat Metab 1, 173–174 (2019).

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