Chiral molecules play indispensable roles in advanced materials and technologies. Nevertheless, no conventional, yet reliable logical strategies are available for designing chiral molecules of desired chiroptical properties. Here, we propose a general protocol for rationally aligning multiple chiral units to boost the chiroptical responses, using hexahelicene as a prototype. In this proof-of-concept study, we align two hexahelicenes in various orientations and examine by theoretical calculations to predict the best chiroptical performance for X-shaped and S-shaped double hexahelicenes. We synthesize and optically resolve both double hexahelicenes and show that they exhibit more than a twofold increase in intensity of circular dichroism and circularly polarized luminescence, experimentally validating the protocol. The enhanced chiroptical responses are theoretically assignable to the electric and magnetic transition dipole moments of component hexahelicenes aligned in the correct symmetry. A guiding principle for designing advanced molecular and supramolecular chiral materials is further discussed.
Possessing unique chiroptical properties, chiral organic molecules1,2 are indispensable components of next-generation smart materials used in various disciplines. Theoretically, all chiroptical properties are related to rotational strength (R), which is defined as the imaginary part of scalar product of the relevant electric (μe) and magnetic (μm) transition dipole moments:3,4,5
The degree of dissymmetry is quantified by the dissymmetry factor (g = 4 R/D), which incorporates the transition probability (dipole strength D). However, the factors and mechanism that control the chiroptical responses in real molecules are not well understood and practically no reliable guidelines have been established for rationally designing chiral molecules with desired chiroptical responses6. Thus, the occasional successes in improving chiroptical properties of organic molecules have been achieved mostly on a trial-and-error basis through inspiration or by chance7,8,9.
Here we show a general protocol for rationally aligning multiple chiral units to boost the chiroptical responses, using hexahelicene as a prototype. In this proof-of-concept study, we demonstrate that aligning two hexahelicenes (HHs) in X-shaped and S-shaped forms can induce more than twice intensified circular dichroism (CD) and circularly polarized luminescence (CPL). Our combined experimental and theoretical investigations also reveal how the molecular symmetry and the alignment of chiral elements determine the CD and CPL responses by manipulating electric and magnetic transition dipole moments of the molecule. The current study provides a reliable guiding principle for designing novel advanced chiral molecules and materials with strong chiroptical responses.
Search for better arrangement of chiral units
Helicenes10,11,12,13 are inherently chiral ortho-fused aromatics and their ground- and excited-state chiroptical properties have been utilized in various fields, including chirality sensing, chiral chromatography, chiral optical force, on-surface asymmetric synthesis, spin filter and CPL materials14,15,16,17,18. In this study, we employed HH19,20 as a prototypical chiral unit to explore the rational protocol for improving the circular dichroism and CPL responses by properly aligning in space (and eventually merging) multiple HH molecules.
Figure 1 illustrates the examined alignments of two (P)-screw chiral HH units placed horizontally (W, S, C2, and X) or stacked vertically (Z) at the van der Waals (vdW) contact distance, all of which were subjected to the computational study for assessing how and to what extent the chiroptical responses are affected by the alignment. We chose the cost-effective time-dependent density functional theory (TD-DFT) with M06-2X functional for estimating the absorption dissymmetry factor (gabs) for the main (1Bb) band relative to that of HH (Supplementary Table 3). As can be seen from the bar graph in Fig. 1, the D2-symmetrically or C2-symmetricallly assembled S, X, and Z outperform the simply sled W and C2, affording much enhanced relative gabs factors of 2.3–4.4 (against HH) for the former but comparable or even worse 0.7–1.1 for the latter. However, repeating twice the S, X, or Z assembly in the same direction (SS, XX, and ZZ) is not or less effective in further improving the already enhanced gabs factors; see the values in the parentheses in Fig. 1.
Of particular interest, the g factor turned out to be less sensitive to the inter-helicene distance. For instance, the relative g factor of S at the vdW distance (4.4) was practically kept unchanged (4.4–4.8) upon separation by 1–10Å, due probably to the effective coupling of electric and magnetic transition moments of each chromophore (vide infra). The g factors calculated for X behaved similarly, varying from 2.3 to 1.5 upon separation of two component HHs by 1 to 10 Å. This means that the component chiral units should not necessarily be in the vdW contact but can be separated and placed in supramolecular, macromolecular and crystal lattices and channels, leaving us much freedom in designing chiroptical materials of higher performance.
Because of the greater enhancement upon double and/or quadruple assembling (Fig. 1), we chose the S and X assemblies for the experimental verification of the theoretical predictions. Since precisely aligning two HH units in a desired geometry is not a trivial task and the inter-chromophore distance does not greatly affect the g factor (vide supra), we decided to prepare molecular analogs as robust, perturbation-free models of the X and S assemblies, in which two HHs are merged at the terminal and central naphthalene moiety to give X-shaped dinaphtho[2,1-i:1′,2′-l]hexahelicene DNH and S-shaped diphenanthro[3,4-c:3′,4′-l]chrysene DPC (Fig. 2a). The structures of such molecules have been theoretically discussed previously21. Both DNH and DPC exhibited extraordinarily intensified CD and CPL responses, as detailed below. State-of-the-art calculations further revealed the decisive role of molecular symmetry (which determines the electric and magnetic transition dipole moments, as well as their relative angle) in attaining the intensified CD and CPL responses of both the double helicenes (Supplementary Table 4). This theory-driven protocol for predicting the ground-state and excited-state chiroptical properties is not restricted to the design of superior chiroptical molecules but is expandable to the design of two-dimensionally and three-dimensionally aligned chiral elements, such as chiral supramolecular assembly22 and chiral surface organization23.
Preparation and structure of double hexahelicenes
Double helicenes are an important target of current research24. Indeed, somewhat exotic double heterohelicenes, containing boron, nitrogen, sulfur or phosphorous, as well as π-expanded double heterohelicenes, have been reported recently25,26,27,28,29,30,31. Also, the coordination of (hetero)helicenes with transition metal(s) has been employed for constructing double and higher helicenoids32. Nevertheless, unsubstituted double helicenes free from hetero atom are still rare (Fig. 2b, D1–D4). Beyond the structural perfectness and beauty, pristine double helicenes are indispensable for better scrutinizing how the photophysical, in particular the chiroptical, properties are affected by molecular symmetry in the absence of the electronic and steric perturbations of hetero atom(s) and/or substituent(s). A number of achiral meso- and chiral dl-double hexahelicenes were reported in the 1970’s33,34,35,36,37. Some of the latter were optically resolved38, but chiroptical properties have not been explored yet for these and related39 double helicenes. Quite recently, the chiroptical properties of three double helicenes with alkyl and/or fused aromatic substituents have become available, but the structure-chiroptical property relationship remain unanswered (Fig. 2b, E1–E3)40,41,42.
Pristine dl-double hexahelicenes DNH and DPC, bearing the C2-symmetry element along the helical axis, were prepared as racemic mixtures (Fig. 2a). The preparation and diastereomer (meso/dl) separation of S-shaped DPC are known32,33, but neither crystal structure nor optical resolution has been reported, while X-shaped DNH is a new compound. Orange-colored single crystals appropriate for X-ray diffraction analyses were obtained for both the dl-double hexahelicenes (Fig. 2a, also see Supplementary Figures 1, 2). The crystal structures of DNH and DPC were slightly deviated from the theoretically predicted D2-symmetric and C2-symmetric structures due to the packing request. Merging two HHs brought about further deformation to the resulting double helicenes, which however localized near the central naphthalene unit and hence the original features of HH were mostly preserved. In the excited state, the helical pitch was predicted to shrink by 0.2 Å for HH but by only 0.1 Å for DNH and DPC, minimizing the undesired losses of excited-state chiroptical responses of the latter two. Extended discussion on the more detailed structural analyses of DNH and DPC in the ground and excited states can be found in the Supplementary Discussion, Supplementary Figure 3 and Supplementary Tables 1, 2.
Optical resolution and circular dichroism of double hexahelicenes
DNH and DPC were optically resolved by chiral HPLC (Supplementary Figures 4, 5). CD spectra of (P,P)-DNH and (P,P)-DPC, as well as (P)-HH, were recorded in dichloromethane at 25 °C (Fig. 3a); for the corresponding UV–Vis spectra and gabs factor profiles, see Supplementary Figure 6. The absolute configuration was unambiguously assigned by comparing the experimental CD spectrum with the theoretical one calculated by the RI-CC2/def2-TZVPP method (Fig. 3a).
(P)-HH exhibits positive and negative Cotton effects (CEs) for the 1Bb and 1Ba bands, respectively (Fig. 3a). (P,P)-DNH and (P,P)-DPC showed apparently similar positive-negative CEs in the same region, but the molar CD (Δε) for the 1Bb transition amounted to +650 and +801 M−1 cm−1, respectively, both of which far exceed twice the value for (P)-HH (+284 M−1 cm−1)43. To the best of our knowledge, the Δε value for DPC is the largest ever reported for non-aggregated or non-oligomerized helicenes and helicenoids. Also, the gabs factors for the 1Bb band of (P,P)-DNH and (P,P)-DPC (+0.016 and +0.022, respectively) are nearly or more than twice the value for (P)-HH (+0.009), confirming enhanced dissymmetry in the double hexahelicenes.
The g factor is an absolute measure of dissymmetry that is already normalized for the transition probability D (as g = 4R/D), but is not directly correlated with the size of molecule. From the viewpoint of attaining optimal chiroptical responses with minimal resource, the g factor per benzene unit (gabs/n) is a more sensible measure of dissymmetry for evaluating and comparing the ability of each benzene unit to induce the overall dissymmetry of helicene. The gabs/n values for the 1Bb and 1Lb bands are 1.5 × 10−3 and 2.0 × 10−4 for the parent hexahelicene, respectively, but increase to 1.6–2.2 × 10−3 and 2.6–2.8 × 10−4 for the double hexahelicenes, respectively. This indicates that the benzene unit in double helicene is 1.1–1.5-fold more efficient than that in single helicene in inducing absorption dissymmetry. This finding that merging two helicenes is 10–50% more resource-efficient than simply assembling them may encourage the molecular, rather than supramolecular, strategy for constructing advanced chiroptical devices.
Electric and magnetic transition dipole moments for 1 B b transition
In contrast to the effects of helix elongation39 and substitution44,45, the effects of symmetry on the chiroptical responses of helicene have been explored only fragmentally. In the pioneering work on S-shaped double azahelicene (H1)46 and X-shaped double thiahelicene (H2)47 (Fig. 2c), the chiroptical properties were described, but no further systematic analyses assisted by theoretical calculations have been done. To better illustrate the origin of the extraordinarily strong chiroptical responses observed for DNH and DPC, we analyze the experimental CD intensities using the three theoretical parameters, μe, μm, and θ (Eq. 1), given by the RI-CC2 calculations. As shown in Fig. 3a, our theoretical calculations reproduced the experimental CD spectra quite satisfactorily.
Figure 4 compares the transition dipole moments calculated for the 1Bb bands of DNH and DPC with those of HH. The 1Bb transition is characteristic to helicene, being aligned along the helical axis39. In X-shaped DNH, the 1Bb band was split into two transitions (Fig. 4 and Supplementary Table 4), the combined |μe| and |μm| of which were comparable to, or even exceed, those of parent HH, while their relative angle θ became nil to maximize the cos θ value to unity in both the transitions that constitute the 1Bb band of DNH. In contrast, the cos θ value for HH was mere 0.24 (θ = 76°). In the case of S-shaped DPC, |μe| was reduced by a factor of 0.78, but |μm| was enhanced by a factor of 1.29, relative to HH, to offset each other. This reveals that the parallel alignment (θ = 0) of the two transition moments (Fig. 4) is the major cause of the unprecedentedly large Δε value of +801 M−1 cm−1 observed for DPC. Intriguingly, the parallel orientation of μe and μm in these double helicenes is qualitatively explained as a vector sum of the transition moments of component HHs (Fig. 4, dashed arrows). Because of the C2-symmetry element along the 1Bb transitions, the vertical components of both transition moments are canceled out and thus the angle θ becomes zero in both the double helicenes.
In brief, the C2-symmetry element along the helical axis of DNH and DPC (which is absent in HH) parallel-aligns the μe and μm moments of the 1Bb transition to maximize the cos θ value and thus the rotational strength R, eventually achieving the extraordinary CD intensities. Such a symmetry-based strategy to parallel-align the electric and magnetic transition dipole moments for stronger CD have never been proposed but should be more effectively exploited in the design of advanced chiroptical materials.
CPL of double hexahelicenes
The photophysical properties of DNH and DPC were further examined and compared with those of parent HH48 (Table 1). As shown in Fig. 3b, the fluorescence spectra of DPC (and HH) have the vibrational fine-structures, while that of DNH is more diffused. The fluorescence 0–0 bands of DNH and DPC appear at 494 and 434 nm, respectively, which are close in energy to the absorption 0–0 bands of the 1Lb transition observed at 471 and 430 nm (Supplementary Figure 7) to afford the small Stokes shifts of 670 and 210 cm−1, respectively. These observations indicate that the excited-state relaxation from the Franck–Condon state is small in energy (and structure) in these double hexahelicenes. Fluorescence quantum yields (Φ) were 0.018 for DNH and 0.041 for DPC, which are appreciably smaller or larger than that for HH (Φ = 0.032), but much larger than those reported for higher homologs (Φ < 0.01)49,50, due to the intersystem crossing progressively accelerated with increasing helicene size. The fluorescence lifetimes (τ) followed the same trend; thus, DPC gave the longest τ of 10.9 ns and DNH the shortest 2.8 ns, while HH came in the middle (τ = 8.4 ns). All of these features (i.e., the highly structured, blue-shifted spectra, larger Φ, longer τ and smaller Stokes shift) observed for DPC, than for DNH, imply that the former is structurally more rigid and deformed than the latter to discourage the conformational and energy relaxation in the excited state.
Despite the strong specific rotation and CD well documented for helicenes, the CPL behavior has attracted less attention until recently51,52,53. The magnitude of CPL is evaluated by the luminescence dissymmetry factor (glum), which is defined as a relative intensity difference between left-circularly and right-circularly polarized emission. Apart from the exceptionally high glum factors of 1-3 × 10−2 reported for S-shaped double azahelicenes42, the glum factors for single helicenes and helicenoids (free from assembling or aggregation) are in the order 10−36,54. Because the fluorescence of helicene usually occurs from the lowest excited singlet (S1) state, the glum factor should correlate with the absorption dissymmetry factor (gabs) for the lowest-energy 1Lb transition of helicene. Recently, the glum and gabs factors have been collected for various helicenes to show a good correlation between them: glum = 0.61 × gabs6.
Figure 3b, compares the experimental and theoretical CPL spectra and the experimental fluorescence spectra of (P,P)-DNH, (P,P)-DPC and (P)-HH. All the (P)- or (P,P)-configured single and double hexahelicenes afforded strong negative CPL. In the CPL spectra (Fig. 3b), both the double helicenes exhibited the same-signed CEs for the 1Lb transition (≥330 nm). Our theoretical calculations at the RI-CC2/def2-TZVPP level well reproduced the sign and emission wavelength of CPL, as well as the relative CPL intensity among the single and double helicenes. Remarkably, the emission of X-shaped DNH was greatly red-shifted to 450–600 nm due to the excited-state relaxation facilitated by the effective π-conjugation. (P,P)-DNH and (P,P)-DPC gave the glum factors of −2.5 × 10−3 and −2.1 × 10−3 (Table 1), which exceeds twice the value for (P)-HH (−0.9 × 10−3). The luminescence dissymmetry factor per benzene unit (glum/n), a quantitative measure of the luminescence dissymmetry caused by each benzene unit, is −1.5 × 10−4 for HH but increases up to −2.5 × 10−4, and −2.1 × 10−4 for DNH and DPC, respectively, indicating that the double helicenes are 40–70% more resource-efficient in generating CPL, as was the case with CD.
These results demonstrate the advantage of possessing C2-symmetry element along the helical axis (and the larger excited-state helical pitches) in these double helicenes. Intriguingly, DNH exhibits comparable glum (−2.5 × 10−3) and gabs (−2.6 × 10−3), whereas the glum of DPC (−2.1 × 10−3) is appreciably smaller than the corresponding gabs (−2.8 × 10−3). Thus, the glum/gabs ratio as a measure of the excited-state relaxation is close to unity (0.96) for DNH but decreases to 0.75 for DPC, both of which are larger than or comparable to the value for HH (0.75). The glum/gabs ratios of double helicenes, especially that for DNH, are larger than that (0.61) obtained as a global average for all the reported helicenes6, confirming the increased rigidity of DNH. The structured fluorescence and CPL spectra urge us to take the vibrational effects into consideration for a more rigorous comparison of the CPL data, which is however not immediately feasible at the level of theory employed and will not be discussed further here. Recently, the importance of vibrational coupling in analyzing the structured CD and CPL spectra of some hexahelicenes has been critically assessed by applying the harmonic approximation to the theoretical treatment55,56.
Electric and magnetic transition dipole moments of 1 L b transition
Figure 5 illustrates the dipole moments of the 1Lb transition of DNH, DPC, and HH calculated for the excited state. The corresponding moments in the ground state are shown in Supplementary Figure 8. These two sets of calculations enable a simulation of the CD and CPL responses upon upward S0-to-S1 and downward S1-to-S0 transition, respectively. As discussed above, the rotational strengths (R) of absorption and emission are functions of the relevant μe, μm, and θ. The small R of −0.5 for the 1Lb band of HH can be traced back to the nearly orthogonal electric and magnetic dipole moments for the upward transition: θ = 94° (or 96°)39,47. The angle θ for the downward transition (CPL) was found appreciably increased to 112°. This apparently small change in θ alone would enhance the R-value by a factor of 5 (as cos 112°/cos 94° = 0.37/0.07) but is nearly canceled out by the smaller |μm| value arising from the decrease in helical pitch to eventually give a comparable R-value of −0.6 for CPL. The increased |μe| values for the double helicenes in the ground and excited states are attributable to the extended π-conjugation, as DNH and DPC contain two HH units merged in a single molecule.
In S-shaped DPC, the angle θ in the ground state was calculated as 95°, almost identical to that of HH. Therefore, the more than doubled gabs factor for the 1Lb band (from −1.2 × 10−3 for HH to −2.8 × 10−3) should be attributed not to θ but to |μe| and |μm| increased by the extended π-conjugation. For the downward transition, θ was further increased to 130°, meaning 7.4-fold enhancement in R (cos 130°/cos 95° = 0.64/0.09) by this factor alone. Indeed, the CPL observed for DPC became considerably stronger (by a factor of 2.3) than that of HH.
In X-shaped DNH, the π-conjugation is extended to supplement the C2-symmetric nature of the parent helicene unit and hence the orientation of 1Lb transition becomes nearly orthogonal to that of HH or DPC, being aligned along the helical axis. Hence, the μe and μm moments are aligned antiparallel, optimizing the orientation factor (cos 180° = −1) in R. However, because of the additional C2-symmetry element in D2 symmetry across the direction of angular momentum, the |μm| was substantially reduced to only moderately enhance the CPL. Nevertheless, the contribution of θ outweighs that of μm to afford the glum of −2.5 × 10−3, which is 2.8-fold larger than that of HH. The contributions of μe and μm are larger in the excited state than in the ground state for both DNH and DPC, reflecting their less contracted helical pitches relative to HH.
In this proof-of-concept study employing X-shaped and S-shaped prsistine double hexahelicenes (DNH and DPC) as representative molecular models, we have developed a theory-guided, symmetry-based protocol for designing advanced molecular and supramolecular chiral systems with enhanced ground-state and excited-state chiroptical responses (CD and CPL), where the alignment of chiral elements plays a decisive role. Thus, DNH and DPC, constructed by merging two hexahelicenes (HH) in D2 and C2 symmetry, achieved the absorption dissymmetry factors per benzene unit (gabs/n) for the 1Bb band that are larger by a factor of up to 1.5 than that of parent HH. This enhancement was well rationalized by the electric (μe) and magnetic (μm) transition dipole moments and their relative angle (θ) evaluated theoretically. In the double helicenes, μe and μm were parallel-aligned (θ = 0) to maximize the orientation factor (cos θ) up to unity, which was mere 0.24 (cos 76°) in HH, while |μe| and |μm| were comparable or only slightly improved. Also, the luminescence dissymmetry factor per benzene unit (glum/n) was up to 1.7-fold larger for the double helicenes than for HH, for which the increased |μe| and θ are responsible. The enhanced gabs/n and glum/n values for double helicenes mean that merging two helicenes is 50–70% more resource-efficient than simply assembling them, which may encourage the molecular, rather than supramolecular, strategy for constructing advanced chiroptical devices.
Our combined experimental and theoretical investigations have further revealed how the molecular symmetry and the alignment of chiral elements determine the CD and CPL responses by manipulating μe, μm and θ. The theoretical analyses deliver an intriguing implication that non-covalently aligning multiple chiral units into a chiral supramolecular assembly is less resource-efficient than merging the same units in a single molecule. Nevertheless, the chiroptical responses of supramolecular assembly are not very sensitive to the inter-chromophore distance to allow compartmentalized assembling of chiral elements in supramolecular/macromolecular/crystal lattices and channels without deteriorating the enhanced chiroptical properties. These results and concepts as well as the insights derived therefrom provide a reliable guiding principle for designing novel advanced chiral molecules and materials with strong chiroptical responses. The basic concepts should be expandable to nano-chirality and mesoscopic chirality composed of numerous rationally organized chiral elements.
Preparation of double hexahelicenes
Full details of general methods, synthetic procedures, and characterization data can be found in the Supplementary Methods. The preparation of racemic double hexahelicene DPC was already described33. Another double hexahelicene DNH was prepared from 7,10-dimethylhexahelicene. This helicene was brominated with N-bromosuccinimide to 7,10-bis(bromomethyl)hexahelicene, which was transformed to the corresponding phosphonium salt. The reaction of this salt with o-iodobenzoaldehyde afforded an isomeric mixture of 7,10-bis[2-(2-iodophenyl)ethenyl]hexahelicenes. Through silica-gel column chromatography, the desired (Z,Z)-isomer, suitable for photocyclization, was isolated. The photocyclization was performed at wavelengths >280 nm in the presence of iodine and tetrahydrofuran in a flow reactor equipped with a high-pressure mercury lamp to afford the desired DNH as a crude racemic mixture. The optical resolutions of DNH and DPC were performed by chiral HPCL using Daicel Chiralpak IA and IB column, respectively, eluted with hexane-dichloromethane with or without ethanol. Crystals suitable for X-ray diffraction analysis were obtained by slow evaporation of solutions of racemic DNH or DPC and the cif files of these and related molecules can be found in Supplementary Data 1. 1H and 13C NMR spectra of all compounds are presented in Supplementary Figures 10–27.
Theoretical calculations were performed on Linux PCs by using the Turbomole or the Gaussian program suite. The TD-DFT calculations on model systems were performed at the M06-2X/def2-TZVP level. Ground-state geometries were fully optimized at the dispersion-corrected density functional theory (3rd generation, DFT-D3 with BJ dumping), using the AO basis-set of valence triple-ξ quality (def2-TZVPP) with the resolution of identity (RI) approximation. Excited-state structures were optimized by the time-dependent, second-order approximate coupled-cluster singles and doubles model, in conjunction with the resolution-of-identity method (RI-CC2 method) with the def2-TZVPP basis-set. The UV–Vis, CD, and CPL spectra were calculated by the same level of theory and the rotational strengths obtained in length gauge were expanded by Gaussian functions, where the bandwidth at 1/e height is fixed at 0.5 eV, unless otherwise stated. Further experimental details can be found in the Supplementary Methods, and the optimized geometries in Supplementary Table 5. Calculated molecular orbitals for DNH, DPC, and HH can be found in Supplementary Figure 9.
The X-ray crystallographic coordinates for structures reported in this Article have been deposited at the Cambridge Crystallographic Data Center (CCDC), under deposition number CCDC 1826743-1826746. These data can be obtained free of charge from The CCDC via www.ccdc.cam.ac.uk/data_request/cif. The additional data that support the findings of this study are available from the corresponding author upon reasonable request.
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Financial supports by Grant-in-Aids for Scientific Research, Challenging Exploratory Research, Promotion of Joint International Research (Fostering Joint International Research), and on Innovative Areas “Photosynergetics” (Grant Numbers JP15H03779, JP15K13642, JP16KK0111, JP17H05261, JP18H01964) from JSPS and by the Asahi Glass Foundation are gratefully acknowledged.
The authors declare no competing interests.
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Tanaka, H., Ikenosako, M., Kato, Y. et al. Symmetry-based rational design for boosting chiroptical responses. Commun Chem 1, 38 (2018). https://doi.org/10.1038/s42004-018-0035-x
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