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Biocatalysis

CYP screening for a better terpenoid world

Nature Catalysis volume 6, pages 983–984 (2023)Cite this article

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Diverse cytochrome P450s (CYPs) in nature can modify terpenoid scaffolds toward products with higher structural complexity and chemical diversity, but their discovery remains challenging. Now, an Escherichia coli -based gene screening platform enables high-throughput bacterial CYP screening, leading to efficient and diverse terpenoid biosynthesis.

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Fig. 1: An engineered E. coli platform enables bacterial CYP screening and diverse terpenoid biosynthesis.

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  1. Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA

    Jianing Han & Sijin Li

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  1. Jianing Han
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  2. Sijin Li
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Correspondence to Sijin Li.

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The authors declare no competing interests.

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Han, J., Li, S. CYP screening for a better terpenoid world. Nat Catal 6, 983–984 (2023). https://doi.org/10.1038/s41929-023-01064-6

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